Type I Interferon Response to Cytomegalovirus Infection: The Kick-Start

SummaryHost responses to cytomegalovirus infection include initial early production of α and β interferons, also called type I interferons, which are elicited directly by viral products via Toll-like receptors. New data indicate that, preceding these events, an earlier critical type I interferon elicited in primary infected stromal cells via the lymphotoxin β receptor system and mediated by B cells is necessary to kick-start an efficient antiviral response