Comparison of mastectomy with breast-conserving surgery in invasive lobular carcinoma: 15-Year results

AbstractBackgroundInvasive lobular cancer (ILC) is biologically distinct from invasive ductal cancer and there is disagreement regarding appropriate local management of this disease.AimThe current study reports long term results comparing mastectomy with breast-conserving surgery (BCS) in the treatment of ILC.Material and methodsStudy includes 235 women with ILC treated between 1983 and 1987. All of them underwent axillary dissection and either mastectomy (n=163) or BCS (n=72). 50Gy adjuvant radiotherapy (RT) was given for 53 BCS and 81 mastectomy patients. The BCS group was compared with the mastectomy group.ResultsPatients treated with mastectomy or BCS had a similar outcome at 15 years with regard to distant metastasis-free (62% vs. 70%; p, 0.2017) and breast cancer-specific (62% vs. 70%; p, 0.1728) survival. In the BCS group the actuarial rate of ipsilateral in breast recurrences was 10% with and 53% without RT at 15 years (relative risk [RR], 0.10; p