The phosphatidylinositol 3-phosphate-binding FYVE finger
- Stenmark, Harald
- Aasland, Rein
- Driscoll, Paul C.
Publication date
February 2002
DOI Publisher
Federation of European Biochemical Societies. Published by Elsevier B.V.Abstract
AbstractThe FYVE zinc finger domain is conserved from yeast (five proteins) to man (27 proteins). It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P), which is found mainly on endosomes. Here we review recent work that sheds light on the targeting of FYVE finger proteins to PI3P-containing membranes, and how these proteins serve to regulate multiple cellular functions
