AbstractThe retinoblastoma gene Rb is the prototype tumor suppressor and is conserved in Drosophila. We use the developing fly retina as a model system to investigate the role of Drosophila Rb (rbf) during differentiation. This report shows that mutation of rbf and rhinoceros (rno), which encodes a PHD domain protein, leads to a synergistic delay in photoreceptor cell differentiation in the developing eye disc. We show that this differentiation delay phenotype is caused by decreased levels of different components of the Epidermal Growth Factor Receptor (EGFR) signaling pathway in the absence of rbf and rno. We show that rbf is required for normal expression of Rhomboid proteins and activation of MAP kinase in the morphogenetic furrow (MF), ...
It has long been known that loss of the retinoblastoma protein (Rb) perturbs neural differentiation,...
AbstractSignaling pathways are often re-used during development in surprisingly different ways. The ...
AbstractThe retinoblastoma tumor suppressor protein (pRb) regulates gene transcription by binding E2...
AbstractThe retinoblastoma gene Rb is the prototype tumor suppressor and is conserved in Drosophila....
AbstractThe retinoblastoma gene Rb is a prototype tumor suppressor which is conserved in Drosophila....
AbstractBackground: During animal development, cells need to make spatially and temporally regulated...
2nd place biological sciences at 2006 Denman Undegrad ForumThe Retinoblastoma (Rb) gene was the firs...
AbstractNotch and EGFR signaling pathways play important roles in photoreceptor differentiation duri...
Background: Retinoblastoma is caused by loss of the Rb protein in early retinal cells. Although nume...
AbstractAnimal organ development requires that tissue patterning and differentiation is tightly coor...
The Retinoblastoma (Rb) gene was the first tumor suppressor discovered. In many, if not all, human t...
AbstractReceptor tyrosine kinases such as the EGF receptor transduce extracellular signals into mult...
It has long been known that loss of the retinoblastoma protein (Rb) perturbs neural differentiation,...
AbstractDominantEllipsemutant alleles of theDrosophilaEGF receptor homologue (DER) dramatically supp...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2003.Includes bibliographi...
It has long been known that loss of the retinoblastoma protein (Rb) perturbs neural differentiation,...
AbstractSignaling pathways are often re-used during development in surprisingly different ways. The ...
AbstractThe retinoblastoma tumor suppressor protein (pRb) regulates gene transcription by binding E2...
AbstractThe retinoblastoma gene Rb is the prototype tumor suppressor and is conserved in Drosophila....
AbstractThe retinoblastoma gene Rb is a prototype tumor suppressor which is conserved in Drosophila....
AbstractBackground: During animal development, cells need to make spatially and temporally regulated...
2nd place biological sciences at 2006 Denman Undegrad ForumThe Retinoblastoma (Rb) gene was the firs...
AbstractNotch and EGFR signaling pathways play important roles in photoreceptor differentiation duri...
Background: Retinoblastoma is caused by loss of the Rb protein in early retinal cells. Although nume...
AbstractAnimal organ development requires that tissue patterning and differentiation is tightly coor...
The Retinoblastoma (Rb) gene was the first tumor suppressor discovered. In many, if not all, human t...
AbstractReceptor tyrosine kinases such as the EGF receptor transduce extracellular signals into mult...
It has long been known that loss of the retinoblastoma protein (Rb) perturbs neural differentiation,...
AbstractDominantEllipsemutant alleles of theDrosophilaEGF receptor homologue (DER) dramatically supp...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2003.Includes bibliographi...
It has long been known that loss of the retinoblastoma protein (Rb) perturbs neural differentiation,...
AbstractSignaling pathways are often re-used during development in surprisingly different ways. The ...
AbstractThe retinoblastoma tumor suppressor protein (pRb) regulates gene transcription by binding E2...