The roles of sphingosine kinases SK1 and SK2 in ischemia–reperfusion injury have not been fully elucidated since studies have found beneficial effects of SK1 while others showed no role in this injury. To help resolve this, we used SK1 or SK2 knockout mice and confirmed that renal ischemia–reperfusion injury induced SK1, but not SK2, in the kidneys. Furthermore, knockout or pharmacological inhibition of SK1 increased injury after renal ischemia–reperfusion injury. In contrast, lack of SK2 conferred renal protection following injury. In addition, we used lentiviral gene delivery to selectively express enhanced green fluorescent protein (EGFP) or human SK1 coexpressed with EGFP (EGFP-huSK1) in the kidney. Mice with kidney-specific overexpress...
Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for...
Sphingosine kinases (SKs) are key enzymes regulating the production of sphingosine-1-phosphate (S1P)...
Genetic deletion of the adenosine A1 receptor (A1AR) increased renal injury following ischemia–reper...
The roles of sphingosine kinases SK1 and SK2 in ischemia–reperfusion injury have not been fully eluc...
Renal ischemia–reperfusion injury is a major cause of acute kidney injury. We previously found that ...
Sphingosine-1-phosphate (S1P), produced by sphingosine kinase 1 (SphK1) or kinase 2 (SphK2), mediate...
We previously showed that activation of the A1 adenosine receptor protected the kidney against ische...
Sphingosine-1-phospate is a lipid mediator that has been implicated in protection from acute kidney ...
The role for the endothelial sphingosine-1-phosphate 1 receptor (S1P1R) in acute kidney injury (AKI)...
The pathogenesis of renal ischemia/reperfusion (I/R) injury involves activating several signal trans...
Both of the sphingosine kinase (SK) subtypes SK-1 and SK-2 catalyze the production of the bioactive ...
Background/Aims: Sphingosine 1-phosphate (S1P) is considered as a key molecule regulating various ce...
BACKGROUND/AIMS Sphingosine 1-phosphate (S1P) is considered as a key molecule regulating various ...
Background/Aims: Sphingosine 1-phosphate (S1P) is considered as a key molecule regulating various ce...
The major sphingolipid metabolite, sphingosine-1-phosphate (S1P), has important biological functions...
Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for...
Sphingosine kinases (SKs) are key enzymes regulating the production of sphingosine-1-phosphate (S1P)...
Genetic deletion of the adenosine A1 receptor (A1AR) increased renal injury following ischemia–reper...
The roles of sphingosine kinases SK1 and SK2 in ischemia–reperfusion injury have not been fully eluc...
Renal ischemia–reperfusion injury is a major cause of acute kidney injury. We previously found that ...
Sphingosine-1-phosphate (S1P), produced by sphingosine kinase 1 (SphK1) or kinase 2 (SphK2), mediate...
We previously showed that activation of the A1 adenosine receptor protected the kidney against ische...
Sphingosine-1-phospate is a lipid mediator that has been implicated in protection from acute kidney ...
The role for the endothelial sphingosine-1-phosphate 1 receptor (S1P1R) in acute kidney injury (AKI)...
The pathogenesis of renal ischemia/reperfusion (I/R) injury involves activating several signal trans...
Both of the sphingosine kinase (SK) subtypes SK-1 and SK-2 catalyze the production of the bioactive ...
Background/Aims: Sphingosine 1-phosphate (S1P) is considered as a key molecule regulating various ce...
BACKGROUND/AIMS Sphingosine 1-phosphate (S1P) is considered as a key molecule regulating various ...
Background/Aims: Sphingosine 1-phosphate (S1P) is considered as a key molecule regulating various ce...
The major sphingolipid metabolite, sphingosine-1-phosphate (S1P), has important biological functions...
Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for...
Sphingosine kinases (SKs) are key enzymes regulating the production of sphingosine-1-phosphate (S1P)...
Genetic deletion of the adenosine A1 receptor (A1AR) increased renal injury following ischemia–reper...