Cells with irreparable genomic damage pose a problem for development and must be eliminated to prevent disease. Reporting in this issue of Developmental Cell, Iampietro et al. (2014) describe a mechanism in Drosophila that removes damaged nuclei from syncytial blastoderm embryos via DNA damage checkpoint kinase-mediated retention of specific mRNAs within the nucleus
For many organisms, the first goal of embryogenesis is to accumulate a large cell population to acco...
SummaryBackgroundThe p53 transcription factor directs a transcriptional program that determines whet...
SummaryBackgroundIn Drosophila embryos, the midblastula transition (MBT) dramatically remodels the c...
SummaryThe faithful execution of embryogenesis relies on the ability of organisms to respond to geno...
AbstractIn syncytial Drosophila embryos, damaged or incompletely replicated DNA triggers centrosome ...
AbstractBackground: Studies in unicellular systems have established that DNA damage by irradiation i...
AbstractBackground: Components of the DNA damage checkpoint are essential for surviving exposure to ...
SummaryCell cycle checkpoints are surveillance mechanisms that safeguard genome integrity. While the...
Exposure to genotoxic stress promotes cell cycle arrest and DNA repair or apoptosis. These “life” or...
Many years of cell-cycle research have been devoted to understanding the mechanisms that replicate a...
We describe the maternal effect phenotype of a hypomorphic mutation in the Drosophila gene for gluta...
AbstractBackground: Cell cycle checkpoints maintain the fidelity of the somatic cell cycle by ensuri...
During normal tissue development, the accumulation of unrepaired cellular and genomic damage can imp...
AbstractBackground:Drosophila embryogenesis is initiated by 13 rapid syncytial mitotic divisions tha...
SummaryThe cell number of the early Drosophila embryo is determined by exactly 13 rounds of synchron...
For many organisms, the first goal of embryogenesis is to accumulate a large cell population to acco...
SummaryBackgroundThe p53 transcription factor directs a transcriptional program that determines whet...
SummaryBackgroundIn Drosophila embryos, the midblastula transition (MBT) dramatically remodels the c...
SummaryThe faithful execution of embryogenesis relies on the ability of organisms to respond to geno...
AbstractIn syncytial Drosophila embryos, damaged or incompletely replicated DNA triggers centrosome ...
AbstractBackground: Studies in unicellular systems have established that DNA damage by irradiation i...
AbstractBackground: Components of the DNA damage checkpoint are essential for surviving exposure to ...
SummaryCell cycle checkpoints are surveillance mechanisms that safeguard genome integrity. While the...
Exposure to genotoxic stress promotes cell cycle arrest and DNA repair or apoptosis. These “life” or...
Many years of cell-cycle research have been devoted to understanding the mechanisms that replicate a...
We describe the maternal effect phenotype of a hypomorphic mutation in the Drosophila gene for gluta...
AbstractBackground: Cell cycle checkpoints maintain the fidelity of the somatic cell cycle by ensuri...
During normal tissue development, the accumulation of unrepaired cellular and genomic damage can imp...
AbstractBackground:Drosophila embryogenesis is initiated by 13 rapid syncytial mitotic divisions tha...
SummaryThe cell number of the early Drosophila embryo is determined by exactly 13 rounds of synchron...
For many organisms, the first goal of embryogenesis is to accumulate a large cell population to acco...
SummaryBackgroundThe p53 transcription factor directs a transcriptional program that determines whet...
SummaryBackgroundIn Drosophila embryos, the midblastula transition (MBT) dramatically remodels the c...
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