AbstractV(D)J recombination is of fundamental importance to the generation of diverse antigen receptor repertoires. We review our current understanding of the V(D)J recombination reaction and how it is regulated during lymphocyte development. We also discuss how defects in the mechanism or regulation of V(D)J recombination can lead to human disease
V(D)J recombination is responsible for the de novo creation of antigen receptor genes in T- and B-ce...
International audienceThe V(D)J recombination machinery assembles antigen receptor genes from germli...
B-cells and T-cells are major components of immunity that detect a large variety of antigens that en...
AbstractV(D)J recombination is of fundamental importance to the generation of diverse antigen recept...
AbstractV(D)J recombination assembles antigen receptor genes from component gene segments. We review...
AbstractA common V(D)J recombinase that recognizes a conserved recombination signal sequence (RSS) m...
In this issue of Immunity, Liu et al. (2007) show that V(D)J recombinase binds chromatin marked by H...
SummaryThe critical initial step in V(D)J recombination, binding of RAG1 and RAG2 to recombination s...
In B lineage progenitors, V(D)J recombination occurs only during distinct stages of development and ...
Expression of V(D)J recombinase activity in developing lymphocytes is absolutely required for initia...
V(D)J recombination is the process that generates the primary antigen receptor repertoire of the ada...
Aberrant recombination between T-cell receptor genes and oncogenes gives rise to chromosomal translo...
SummaryVariable (V), diversity (D), and joining (J) (V(D)J) recombination is the first determinant o...
AbstractV(D)J recombination occurs efficiently only between gene segments flanked by recombination s...
AbstractV(D)J recombination assembles the variable portion of antigen receptor genes in developing l...
V(D)J recombination is responsible for the de novo creation of antigen receptor genes in T- and B-ce...
International audienceThe V(D)J recombination machinery assembles antigen receptor genes from germli...
B-cells and T-cells are major components of immunity that detect a large variety of antigens that en...
AbstractV(D)J recombination is of fundamental importance to the generation of diverse antigen recept...
AbstractV(D)J recombination assembles antigen receptor genes from component gene segments. We review...
AbstractA common V(D)J recombinase that recognizes a conserved recombination signal sequence (RSS) m...
In this issue of Immunity, Liu et al. (2007) show that V(D)J recombinase binds chromatin marked by H...
SummaryThe critical initial step in V(D)J recombination, binding of RAG1 and RAG2 to recombination s...
In B lineage progenitors, V(D)J recombination occurs only during distinct stages of development and ...
Expression of V(D)J recombinase activity in developing lymphocytes is absolutely required for initia...
V(D)J recombination is the process that generates the primary antigen receptor repertoire of the ada...
Aberrant recombination between T-cell receptor genes and oncogenes gives rise to chromosomal translo...
SummaryVariable (V), diversity (D), and joining (J) (V(D)J) recombination is the first determinant o...
AbstractV(D)J recombination occurs efficiently only between gene segments flanked by recombination s...
AbstractV(D)J recombination assembles the variable portion of antigen receptor genes in developing l...
V(D)J recombination is responsible for the de novo creation of antigen receptor genes in T- and B-ce...
International audienceThe V(D)J recombination machinery assembles antigen receptor genes from germli...
B-cells and T-cells are major components of immunity that detect a large variety of antigens that en...
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