SummaryAdult stem cells are the ultimate source for replenishment of salivary gland (SG) tissue. Self-renewal ability of stem cells is dependent on extrinsic niche signals that have not been unraveled for the SG. The ductal compartment in SG has been identified as the location harboring stem cells. Here, we report that rare SG ductal EpCAM+ cells express nuclear β-catenin, indicating active Wnt signaling. In cell culture experiments, EpCAMhigh cells respond potently to Wnt signals stimulating self-renewal and long-term expansion of SG organoids, containing all differentiated SG cell types. Conversely, Wnt inhibition ablated long-term organoid cultures. Finally, transplantation of cells pre-treated with Wnt agonists into submandibular glands...
We show that activation of Wnt/{beta}-catenin and attenuation of Bmp signals, by combined gain- and ...
SummaryCurrent dogma suggests that salivary gland homeostasis is stem cell dependent. However, the e...
AbstractBackground and purposeSalivary gland dysfunction is a major side effect of radiotherapy for ...
Adult stem cells are the ultimate source for replenishment of salivary gland (SG) tissue. Self-renew...
SummaryAdult stem cells are the ultimate source for replenishment of salivary gland (SG) tissue. Sel...
Adult stem cells are the ultimate source for replenishment of salivary gland (SG) tissue. Self-renew...
Adult stem cells are the ultimate source for replenishment of salivary gland (SG) tissue. Self-renew...
SummaryHyposalivation often leads to irreversible and untreatable xerostomia. Salivary gland (SG) st...
SummaryAdult stem cells have the ability to self-renew and to generate specialized cells. Self-renew...
Hyposalivation often leads to irreversible and untreatable xerostomia. Salivary gland (SG) stem cell...
BACKGROUND: Three-dimensional (3D) cultures recapitulate the microenvironment of tissue-resident ste...
Adult stem cells are often touted as therapeutic agents in the regenerative medicine field, however ...
Adult stem cells hold great promise for regenerative medicine, yet it is difficult to expand such ce...
Dysfunction of the salivary gland and irreversible hyposalivation are the main side effects of radio...
We show that activation of Wnt/{beta}-catenin and attenuation of Bmp signals, by combined gain- and ...
SummaryCurrent dogma suggests that salivary gland homeostasis is stem cell dependent. However, the e...
AbstractBackground and purposeSalivary gland dysfunction is a major side effect of radiotherapy for ...
Adult stem cells are the ultimate source for replenishment of salivary gland (SG) tissue. Self-renew...
SummaryAdult stem cells are the ultimate source for replenishment of salivary gland (SG) tissue. Sel...
Adult stem cells are the ultimate source for replenishment of salivary gland (SG) tissue. Self-renew...
Adult stem cells are the ultimate source for replenishment of salivary gland (SG) tissue. Self-renew...
SummaryHyposalivation often leads to irreversible and untreatable xerostomia. Salivary gland (SG) st...
SummaryAdult stem cells have the ability to self-renew and to generate specialized cells. Self-renew...
Hyposalivation often leads to irreversible and untreatable xerostomia. Salivary gland (SG) stem cell...
BACKGROUND: Three-dimensional (3D) cultures recapitulate the microenvironment of tissue-resident ste...
Adult stem cells are often touted as therapeutic agents in the regenerative medicine field, however ...
Adult stem cells hold great promise for regenerative medicine, yet it is difficult to expand such ce...
Dysfunction of the salivary gland and irreversible hyposalivation are the main side effects of radio...
We show that activation of Wnt/{beta}-catenin and attenuation of Bmp signals, by combined gain- and ...
SummaryCurrent dogma suggests that salivary gland homeostasis is stem cell dependent. However, the e...
AbstractBackground and purposeSalivary gland dysfunction is a major side effect of radiotherapy for ...