SummaryLeßmann et al. present a chiral natural-product-derived library of α,β-unsaturated δ-lactones obtained through stereoselective synthesis on a solid support [1]. Phenotypic screening of this compound collection provided new modulators of cell cycle progression and of viral cell entry with high hit rates
Natural products are the richest known source of small molecules that bind proteins with high specif...
Chemical compounds isolated from natural sources offer unique opportunities to understand life on a ...
Due to the growing interest in small molecules that could help in understanding protein-protein inte...
SummaryLeßmann et al. present a chiral natural-product-derived library of α,β-unsaturated δ-lactones...
SummaryThe underlying frameworks of natural product classes with multiple biological activities can ...
The underlying frameworks of natural product classes with multiple biological activities can be rega...
Les macrolides du résorcinol présentant une fonction cis-enone se sont révélés être de puissants et ...
Natural products that act as highly specific, small-molecule protein-binding agents and as modulator...
Purpose: In the battle against cancer discovery of new and novel chemotherapeutic agent demands extr...
A history and detailed account of the applications of β-lactones towards natural products and bioact...
Cancer is one of the leading causes of death globally, accounting for an estimated 8 million deaths ...
AbstractIn the age of high-throughput biology, novel genes and proteins are emerging quickly. The ne...
In this issue of Chemistry & Biology, Li and Lawrence [1] report an iterative synthesis/selection pr...
It was by way of total synthesis that the issues concerning the stereostructure of leiodermatolide (...
Flavaglines are a class of natural products with potent insecticidal and anticancer activities. β-La...
Natural products are the richest known source of small molecules that bind proteins with high specif...
Chemical compounds isolated from natural sources offer unique opportunities to understand life on a ...
Due to the growing interest in small molecules that could help in understanding protein-protein inte...
SummaryLeßmann et al. present a chiral natural-product-derived library of α,β-unsaturated δ-lactones...
SummaryThe underlying frameworks of natural product classes with multiple biological activities can ...
The underlying frameworks of natural product classes with multiple biological activities can be rega...
Les macrolides du résorcinol présentant une fonction cis-enone se sont révélés être de puissants et ...
Natural products that act as highly specific, small-molecule protein-binding agents and as modulator...
Purpose: In the battle against cancer discovery of new and novel chemotherapeutic agent demands extr...
A history and detailed account of the applications of β-lactones towards natural products and bioact...
Cancer is one of the leading causes of death globally, accounting for an estimated 8 million deaths ...
AbstractIn the age of high-throughput biology, novel genes and proteins are emerging quickly. The ne...
In this issue of Chemistry & Biology, Li and Lawrence [1] report an iterative synthesis/selection pr...
It was by way of total synthesis that the issues concerning the stereostructure of leiodermatolide (...
Flavaglines are a class of natural products with potent insecticidal and anticancer activities. β-La...
Natural products are the richest known source of small molecules that bind proteins with high specif...
Chemical compounds isolated from natural sources offer unique opportunities to understand life on a ...
Due to the growing interest in small molecules that could help in understanding protein-protein inte...
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