Thrombocytopenia associated with chronic liver disease
- Afdhal, Nezam
- McHutchison, John
- Brown, Robert
- Jacobson, Ira
- Manns, Michael
- Poordad, Fred
- Weksler, Babette
- Esteban, Rafael
DOIAbstract
Thrombocytopenia (platelet count <150,000/μL) is a common complication in patients with chronic liver disease (CLD) that has been observed in up to 76% of patients. Moderate thrombocytopenia (platelet count, 50,000/μL–75,000/μL) occurs in approximately 13% of patients with cirrhosis. Multiple factors can contribute to the development of thrombocytopenia, including splenic platelet sequestration, bone marrow suppression by chronic hepatitis C infection, and antiviral treatment with interferon-based therapy. Reductions in the level or activity of the hematopoietic growth factor thrombopoietin (TPO) may also play a role. Thrombocytopenia can impact routine care of patients with CLD, potentially postponing or interfering with diagnostic and the...
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