Factors influencing calcification of cardiac bioprostheses in adolescent sheep
- Flameng, Willem
- Meuris, Bart
- Yperman, Jessa
- De Visscher, Geofrey
- Herijgers, Paul
- Verbeken, Erik
DOIAbstract
ObjectiveWe determined the possible effects of age, antimineralization treatments, circulatory implant conditions, prosthesis design, and valve-related structural aspects on valve calcification in adolescent sheep.MethodsCalcium content was measured by means of atomic absorption spectrometry in bioprostheses implanted in 120 sheep (age <1 year) for a period of 3 or 6 months.ResultsBioprostheses calcified significantly in adolescent sheep, but the extent of calcification was multifactorial. Multivariate analysis of the calcium content reveals that age, mitral or pulmonary implant position, prosthesis design (stented or stentless), structure (porcine or pericardial, wall portion or cusp), and antimineralization treatment are independent facto...
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