Mutations of ALK are frequently observed in MYCN-amplified neuroblastomas and correlate with poor clinical outcome, but how these oncogenes cooperate in neuroblastoma development remains unclear. In this issue of Cancer Cell, Zhu et al. describe a mechanism by which ALK and MYCN synergistically induce neuroblastoma in the zebrafish model system
Earlier reports showed that hyperplasia of sympathoadrenal cell precursors during embryogenesis in N...
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that was first reported as a fusion p...
Background: In neuroblastoma (NB), the ALK receptor tyrosine kinase can be constitutively activated...
Mutations of ALK are frequently observed in MYCN-amplified neuroblastomas and correlate with poor cl...
SummaryAmplification of the MYCN oncogene in childhood neuroblastoma is often accompanied by mutatio...
The anaplastic lymphoma kinase (ALK) gene is overexpressed, mutated or amplified in most neuroblasto...
Background: Activating mutations of the anaplastic lymphoma receptor tyrosine kinase gene (ALK) were...
Activating anaplastic lymphoma kinase (ALK) mutations were recently detected in most familial and 10...
High-risk neuroblastoma (NB) is responsible for a disproportionate number of childhood deaths due to...
High-risk neuroblastoma (NB) is responsible for a disproportionate number of childhood deaths due to...
SummaryGenetic studies have established anaplastic lymphoma kinase (ALK), a cell surface receptor ty...
Background: In neuroblastoma (NB), the ALK receptor tyrosine kinase can be constitutively activated ...
Introduction: MYCN signaling plays a key role in initiation and progression of neuroblastoma (NB). M...
Neuroblastonna is an embryonal tumor with a heterogeneous clinical course. The tumor is presumed to ...
Nearly half of patients with neuroblastoma present with high-risk disease, which often has poor outc...
Earlier reports showed that hyperplasia of sympathoadrenal cell precursors during embryogenesis in N...
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that was first reported as a fusion p...
Background: In neuroblastoma (NB), the ALK receptor tyrosine kinase can be constitutively activated...
Mutations of ALK are frequently observed in MYCN-amplified neuroblastomas and correlate with poor cl...
SummaryAmplification of the MYCN oncogene in childhood neuroblastoma is often accompanied by mutatio...
The anaplastic lymphoma kinase (ALK) gene is overexpressed, mutated or amplified in most neuroblasto...
Background: Activating mutations of the anaplastic lymphoma receptor tyrosine kinase gene (ALK) were...
Activating anaplastic lymphoma kinase (ALK) mutations were recently detected in most familial and 10...
High-risk neuroblastoma (NB) is responsible for a disproportionate number of childhood deaths due to...
High-risk neuroblastoma (NB) is responsible for a disproportionate number of childhood deaths due to...
SummaryGenetic studies have established anaplastic lymphoma kinase (ALK), a cell surface receptor ty...
Background: In neuroblastoma (NB), the ALK receptor tyrosine kinase can be constitutively activated ...
Introduction: MYCN signaling plays a key role in initiation and progression of neuroblastoma (NB). M...
Neuroblastonna is an embryonal tumor with a heterogeneous clinical course. The tumor is presumed to ...
Nearly half of patients with neuroblastoma present with high-risk disease, which often has poor outc...
Earlier reports showed that hyperplasia of sympathoadrenal cell precursors during embryogenesis in N...
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that was first reported as a fusion p...
Background: In neuroblastoma (NB), the ALK receptor tyrosine kinase can be constitutively activated...
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