AbstractProtein kinase B (AKT) and glycogen synthase kinase-3β (GSK-3β) are major components of insulin–AKT signaling that plays crucial roles in various types of tissue. Recent studies found that these two kinases are modified posttranslationally by O-GlcNAcylation. Here, we demonstrate that O-GlcNAcylation regulated phosphorylation/activation of AKT and GSK-3β in different manners in kidney HEK-293FT cells, but did not affect these two kinases in hepatic HepG2 cells. In neuronal cells, O-GlcNAcylation regulated phosphorylation of AKT negatively, but had no effect on GSK-3β. These results suggest protein-specific and cell type-specific regulation of AKT and GSK-3β by O-GlcNAcylation. Therefore, studies on the roles of AKT and GSK-3β O-GlcN...
The phosphatidylinositol 3-kinase (PI3K) pathway, through its major effector node AKT, is critical f...
The nutrient sensor, O-linked N-acetylglucosamine (O-GlcNAc), cycles on and off nuclear and cytosoli...
AbstractPhosphatidylinositol 3-kinase pathways play key regulatory roles in cell cycle progression i...
AbstractProtein kinase B (AKT) and glycogen synthase kinase-3β (GSK-3β) are major components of insu...
O-linked N-acetylglucosamine glycosylations (O-GlcNAc) and O-linked phosphorylations (O-phosphate), ...
O-GlcNAc transferase (OGT)-mediated modification of protein Ser/Thr residues withO-GlcNAc influences...
AbstractSer(Thr)-O-linked β-N-acetylglucosamine (O-GlcNAc) is a ubiquitous modification of nucleocyt...
The hexosamine biosynthetic pathway (HBP) and the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian...
dissertationAttachment of O-linked (3-N-acetylglucosamine (O-GlcNAc) to the hydroxyl group of serin...
International audienceO-GlcNAc glycosylation (O-GlcNAcylation) corresponds to the addition of N-acet...
SummaryAlthough the class IA phosphoinositide 3-kinase (PI3K) pathway is central to the metabolic ac...
AbstractWe examined whether extracellular signals regulate glycogen synthase kinase-3 (GSK-3) activi...
SummaryGlycogen synthase kinase 3 comprises two isoforms (GSK-3α and GSK-3β) that are implicated in ...
<div><p><em>O</em>-linked N-acetylglucosamine glycosylations (<em>O</em>-GlcNAc) and <em>O</em>-link...
AbstractIncreased flux through the hexosamine biosynthetic pathway (HBP) has been shown to affect th...
The phosphatidylinositol 3-kinase (PI3K) pathway, through its major effector node AKT, is critical f...
The nutrient sensor, O-linked N-acetylglucosamine (O-GlcNAc), cycles on and off nuclear and cytosoli...
AbstractPhosphatidylinositol 3-kinase pathways play key regulatory roles in cell cycle progression i...
AbstractProtein kinase B (AKT) and glycogen synthase kinase-3β (GSK-3β) are major components of insu...
O-linked N-acetylglucosamine glycosylations (O-GlcNAc) and O-linked phosphorylations (O-phosphate), ...
O-GlcNAc transferase (OGT)-mediated modification of protein Ser/Thr residues withO-GlcNAc influences...
AbstractSer(Thr)-O-linked β-N-acetylglucosamine (O-GlcNAc) is a ubiquitous modification of nucleocyt...
The hexosamine biosynthetic pathway (HBP) and the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian...
dissertationAttachment of O-linked (3-N-acetylglucosamine (O-GlcNAc) to the hydroxyl group of serin...
International audienceO-GlcNAc glycosylation (O-GlcNAcylation) corresponds to the addition of N-acet...
SummaryAlthough the class IA phosphoinositide 3-kinase (PI3K) pathway is central to the metabolic ac...
AbstractWe examined whether extracellular signals regulate glycogen synthase kinase-3 (GSK-3) activi...
SummaryGlycogen synthase kinase 3 comprises two isoforms (GSK-3α and GSK-3β) that are implicated in ...
<div><p><em>O</em>-linked N-acetylglucosamine glycosylations (<em>O</em>-GlcNAc) and <em>O</em>-link...
AbstractIncreased flux through the hexosamine biosynthetic pathway (HBP) has been shown to affect th...
The phosphatidylinositol 3-kinase (PI3K) pathway, through its major effector node AKT, is critical f...
The nutrient sensor, O-linked N-acetylglucosamine (O-GlcNAc), cycles on and off nuclear and cytosoli...
AbstractPhosphatidylinositol 3-kinase pathways play key regulatory roles in cell cycle progression i...