Recently reporting in Nature, Barber et al. demonstrated that SIRT7 maintains critical features that define cancer cells by removing the acetylation mark on lysine 18 of histone H3. Interestingly, hypoacetylation of H3K18 has been described as a general marker of tumor prognosis and oncoviral transformation
Members of sirtuin family regulate multiple critical biological processes, yet their role in carcino...
SummaryChromatin factors have emerged as the most frequently dysregulated family of proteins in canc...
In this issue of Cancer Cell, Finley and coworkers report that the genetic loss of the deacetylase S...
Recently reporting in Nature, Barber et al. demonstrated that SIRT7 maintains critical features that...
Acetylation regulation plays an important role in various kinds of physiological processes, dysregul...
SIRT7 is one of seven mammalian sirtuins that functions as an NAD+-dependent histone/protein deacety...
SummaryIn lower eukaryotes, Sir2 serves as a histone deacetylase and is implicated in chromatin sile...
Cancer stem cells (CSCs) have high tumorigenic capacity. Here, we show that stem-like traits of spec...
For eukaryotes, DNA is maintained in the form of chromatin, which is comprised of millions of repeat...
""Sirtuins represent a promising new class of conserved histone deacetylases, originally identified ...
Sirtuin deacetylases are linked to longevity, aging, and stress responses. In this issue of Cancer C...
Sirtuin 1 (SIRT1), an NAD+ -dependent histone/protein deacetylase, has multifaceted functions in var...
Hongfeng Yuan,1 Leila Su,2 WenYong Chen1 1Department of Cancer Biology, 2Department of Molecular Med...
Chromatin factors have emerged as the most frequently dysregulated family of proteins in cancer. We ...
Sirtuins (SIRTs), class III histone deacetylases, are differentially expressed in several human canc...
Members of sirtuin family regulate multiple critical biological processes, yet their role in carcino...
SummaryChromatin factors have emerged as the most frequently dysregulated family of proteins in canc...
In this issue of Cancer Cell, Finley and coworkers report that the genetic loss of the deacetylase S...
Recently reporting in Nature, Barber et al. demonstrated that SIRT7 maintains critical features that...
Acetylation regulation plays an important role in various kinds of physiological processes, dysregul...
SIRT7 is one of seven mammalian sirtuins that functions as an NAD+-dependent histone/protein deacety...
SummaryIn lower eukaryotes, Sir2 serves as a histone deacetylase and is implicated in chromatin sile...
Cancer stem cells (CSCs) have high tumorigenic capacity. Here, we show that stem-like traits of spec...
For eukaryotes, DNA is maintained in the form of chromatin, which is comprised of millions of repeat...
""Sirtuins represent a promising new class of conserved histone deacetylases, originally identified ...
Sirtuin deacetylases are linked to longevity, aging, and stress responses. In this issue of Cancer C...
Sirtuin 1 (SIRT1), an NAD+ -dependent histone/protein deacetylase, has multifaceted functions in var...
Hongfeng Yuan,1 Leila Su,2 WenYong Chen1 1Department of Cancer Biology, 2Department of Molecular Med...
Chromatin factors have emerged as the most frequently dysregulated family of proteins in cancer. We ...
Sirtuins (SIRTs), class III histone deacetylases, are differentially expressed in several human canc...
Members of sirtuin family regulate multiple critical biological processes, yet their role in carcino...
SummaryChromatin factors have emerged as the most frequently dysregulated family of proteins in canc...
In this issue of Cancer Cell, Finley and coworkers report that the genetic loss of the deacetylase S...
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