AbstractA population of catalytic RNA molecules has been engineered to operate and evolve in vitro in a continuous manner. The novel continuity of the process allows the propagation of many generations in a very short time and without the manual manipulation necessary with traditional in vitro selection techniques
We are interested in the biochemistry of existing RNA enzymes and in the development of RNA enzymes ...
The RNA-based organisms from which modern life is thought to have descended would have depended on a...
AbstractThe recent selection of a complex ribozyme capable of general polymerization on a template i...
AbstractA population of catalytic RNA molecules has been engineered to operate and evolve in vitro i...
According to the "RNA World Hypothesis" the first self replicating molecule formed from th...
AbstractVariants of the class I ligase ribozyme, which catalyzes joining of the 3′ end of a template...
In an earlier study, an in vitro evolution procedure was applied to a large population of variants o...
AbstractBackground: In vitro evolution has been used to obtain nucleic acid molecules with interesti...
The biggest challenge for origin-of-life scientists is to account for the first self-replicating mol...
It is generally thought that prior to the origin of protein synthesis, life on earth was based on se...
SummaryAn RNA ligase ribozyme was converted to a corresponding deoxyribozyme through in vitro evolut...
AbstractThe theory that an RNA world played a pivotal role in life's evolutionary past has prompted ...
In order to explore the variety of possible responses available to a ribozyme population evolving a ...
AbstractThe isolation of an RNA enzyme with RNA replicase activity, at present only a hypothetical m...
Our current understanding of biology suggests that early life relied predominantly on RNA for both c...
We are interested in the biochemistry of existing RNA enzymes and in the development of RNA enzymes ...
The RNA-based organisms from which modern life is thought to have descended would have depended on a...
AbstractThe recent selection of a complex ribozyme capable of general polymerization on a template i...
AbstractA population of catalytic RNA molecules has been engineered to operate and evolve in vitro i...
According to the "RNA World Hypothesis" the first self replicating molecule formed from th...
AbstractVariants of the class I ligase ribozyme, which catalyzes joining of the 3′ end of a template...
In an earlier study, an in vitro evolution procedure was applied to a large population of variants o...
AbstractBackground: In vitro evolution has been used to obtain nucleic acid molecules with interesti...
The biggest challenge for origin-of-life scientists is to account for the first self-replicating mol...
It is generally thought that prior to the origin of protein synthesis, life on earth was based on se...
SummaryAn RNA ligase ribozyme was converted to a corresponding deoxyribozyme through in vitro evolut...
AbstractThe theory that an RNA world played a pivotal role in life's evolutionary past has prompted ...
In order to explore the variety of possible responses available to a ribozyme population evolving a ...
AbstractThe isolation of an RNA enzyme with RNA replicase activity, at present only a hypothetical m...
Our current understanding of biology suggests that early life relied predominantly on RNA for both c...
We are interested in the biochemistry of existing RNA enzymes and in the development of RNA enzymes ...
The RNA-based organisms from which modern life is thought to have descended would have depended on a...
AbstractThe recent selection of a complex ribozyme capable of general polymerization on a template i...
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