AbstractMitochondrial radical production is important in redox signaling, aging and disease, but the relative contributions of different production sites are poorly understood. We analyzed the rates of superoxide/H2O2 production from different defined sites in rat skeletal muscle mitochondria oxidizing a variety of conventional substrates in the absence of added inhibitors: succinate; glycerol 3-phosphate; palmitoylcarnitine plus carnitine; or glutamate plus malate. In all cases, the sum of the estimated rates accounted fully for the measured overall rates. There were two striking results. First, the overall rates differed by an order of magnitude between substrates. Second, the relative contribution of each site was very different with dif...
AbstractOverproduction of reactive oxygen species (ROS) has been implicated in a range of pathologie...
AbstractThe relationship between the rate of superoxide production by complex I and NAD(P)H redox st...
AbstractReactive oxygen species (ROS) have been widely implicated in the pathogenesis of various neu...
Mitochondrial radical production is important in redox signaling, aging and disease, but the relativ...
AbstractReactive oxygen species (ROS) have been widely implicated in the pathogenesis of various neu...
AbstractDehydrogenases that use ubiquinone as an electron acceptor, including complex I of the respi...
Reactive oxygen species are a by-product of mitochondrial oxidative phosphorylation, derived from a ...
AbstractThe impact of complex II (succinate:ubiquinone oxidoreductase) on the mitochondrial producti...
Reactive oxygen species are a by-product of mitochondrial oxidative phosphorylation, derived from a ...
Mitochondria-produced reactive oxygen species (ROS) are thought to contribute to cell death caused b...
AbstractMitochondria are often regarded as a major source of reactive oxygen species (ROS) in animal...
AbstractDehydrogenases that use ubiquinone as an electron acceptor, including complex I of the respi...
AbstractThe mitochondrial respiratory chain is a powerful source of reactive oxygen species, conside...
AbstractApart from complex I (NADH:ubiquinone oxidoreductase) the mitochondrial cytochrome bc1 compl...
AbstractThe observation that in isolated mitochondria electrons may leak out of the respiratory chai...
AbstractOverproduction of reactive oxygen species (ROS) has been implicated in a range of pathologie...
AbstractThe relationship between the rate of superoxide production by complex I and NAD(P)H redox st...
AbstractReactive oxygen species (ROS) have been widely implicated in the pathogenesis of various neu...
Mitochondrial radical production is important in redox signaling, aging and disease, but the relativ...
AbstractReactive oxygen species (ROS) have been widely implicated in the pathogenesis of various neu...
AbstractDehydrogenases that use ubiquinone as an electron acceptor, including complex I of the respi...
Reactive oxygen species are a by-product of mitochondrial oxidative phosphorylation, derived from a ...
AbstractThe impact of complex II (succinate:ubiquinone oxidoreductase) on the mitochondrial producti...
Reactive oxygen species are a by-product of mitochondrial oxidative phosphorylation, derived from a ...
Mitochondria-produced reactive oxygen species (ROS) are thought to contribute to cell death caused b...
AbstractMitochondria are often regarded as a major source of reactive oxygen species (ROS) in animal...
AbstractDehydrogenases that use ubiquinone as an electron acceptor, including complex I of the respi...
AbstractThe mitochondrial respiratory chain is a powerful source of reactive oxygen species, conside...
AbstractApart from complex I (NADH:ubiquinone oxidoreductase) the mitochondrial cytochrome bc1 compl...
AbstractThe observation that in isolated mitochondria electrons may leak out of the respiratory chai...
AbstractOverproduction of reactive oxygen species (ROS) has been implicated in a range of pathologie...
AbstractThe relationship between the rate of superoxide production by complex I and NAD(P)H redox st...
AbstractReactive oxygen species (ROS) have been widely implicated in the pathogenesis of various neu...