SummaryWe demonstrate that PTEN loss causes reduced NKX3.1 expression in both murine and human prostate cancers. Restoration of Nkx3.1 expression in vivo in Pten null epithelium leads to decreased cell proliferation, increased cell death, and prevention of tumor initiation. Whereas androgen receptor (AR) positively regulates NKX3.1 expression, NKX3.1 negatively modulates AR transcription and consequently the AR-associated signaling events. Consistent with its tumor suppressor functions, NKX3.1 engages cell cycle and cell death machinery via association with HDAC1, leading to increased p53 acetylation and half-life through MDM2-dependent mechanisms. Importantly, overexpression of Nkx3.1 has little effect on Pten wild-type epithelium, suggest...
Abstract PTEN is one of the most commonly deleted/mutated tumor suppressor genes in human prostate c...
Gene expression and functional studies have indicated that the molecular programmes in-volved in pro...
AbstractWe show in this study that PTEN regulates p53 protein levels and transcriptional activity th...
NKX3.1 is the most commonly deleted gene in prostate cancer and a gatekeeper suppressor. NKX3.1 is a...
SummaryAlthough most oncogenic phenotypes of PTEN loss are attributed to AKT activation, AKT alone i...
Inactivating PTEN mutations are commonly found in prostate cancer, resulting in an increased activat...
ABSTRACT NKX3.1 and PTEN genes are involved in the development and progression of prostate cancer (P...
SummaryAlteration of the PTEN/PI3K pathway is associated with late-stage and castrate-resistant pros...
AbstractThe murine Pten prostate cancer model described in this study recapitulates the disease prog...
Complete inactivation of the PTEN tumor suppressor gene is extremely common in advanced cancer, incl...
SummaryProstate cancer is characterized by its dependence on androgen receptor (AR) and frequent act...
Complete inactivation of the PTEN tumor suppressor gene is extremely common in advanced cancer, incl...
Although it is known that inflammation plays a critical role in prostate tumorigenesis, the underlyi...
SummaryHyperactivation of the PI 3-kinase/AKT pathway is a driving force of many cancers. Here we id...
In aging men, the prostate gland becomes hyperproliferative and displays a propensity toward carcino...
Abstract PTEN is one of the most commonly deleted/mutated tumor suppressor genes in human prostate c...
Gene expression and functional studies have indicated that the molecular programmes in-volved in pro...
AbstractWe show in this study that PTEN regulates p53 protein levels and transcriptional activity th...
NKX3.1 is the most commonly deleted gene in prostate cancer and a gatekeeper suppressor. NKX3.1 is a...
SummaryAlthough most oncogenic phenotypes of PTEN loss are attributed to AKT activation, AKT alone i...
Inactivating PTEN mutations are commonly found in prostate cancer, resulting in an increased activat...
ABSTRACT NKX3.1 and PTEN genes are involved in the development and progression of prostate cancer (P...
SummaryAlteration of the PTEN/PI3K pathway is associated with late-stage and castrate-resistant pros...
AbstractThe murine Pten prostate cancer model described in this study recapitulates the disease prog...
Complete inactivation of the PTEN tumor suppressor gene is extremely common in advanced cancer, incl...
SummaryProstate cancer is characterized by its dependence on androgen receptor (AR) and frequent act...
Complete inactivation of the PTEN tumor suppressor gene is extremely common in advanced cancer, incl...
Although it is known that inflammation plays a critical role in prostate tumorigenesis, the underlyi...
SummaryHyperactivation of the PI 3-kinase/AKT pathway is a driving force of many cancers. Here we id...
In aging men, the prostate gland becomes hyperproliferative and displays a propensity toward carcino...
Abstract PTEN is one of the most commonly deleted/mutated tumor suppressor genes in human prostate c...
Gene expression and functional studies have indicated that the molecular programmes in-volved in pro...
AbstractWe show in this study that PTEN regulates p53 protein levels and transcriptional activity th...