Systemic Levels of Cotinine and Elastase, but not Pulmonary Function, are Associated with the Progression of Small Abdominal Aortic Aneurysms
- Lindholt, J.S.
- Jørgensen, B.
- Klitgaard, N.A.
- Henneberg, E.W.
DOIAbstract
AbstractObjective: to study whether smoking and impaired pulmonary function are associated with the expansion of abdominal aortic aneurysms (AAA).Methods and material: seventy-nine men with small (3–5 cm), screen-detected AAA underwent a simple 5-step smoking history, measurement of the forced first second expiratory volume (FEV1), venepuncture and annual ultrasound scan for mean follow-up period of 3.5 years.Results: all but one patient had a significantly reduced FEV1 (p<0.05, Mann–Whitney). The FEV1/expected FEV1 ratio (rFEV1) was not related to AAA expansion but was negatively correlated with P-elastase-α1-antitrypsin-complexes (P-Elastase). P-Elastase was positively correlated with smoking and S-cotinine. Smoking, S-cotinine, and P-ela...
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