Carcinoma da próstata metastático resistente à castração - novas abordagens terapêuticas

AbstractProstate cancer is the most common noncutaneous malignancy in males and the second cause of cancer related mortality amongst men in the Western World. It is estimated that up to 40% of individuals diagnosed with this tumor will develop metastatic disease. Although there is a favorable initial response to medical or surgical castration, progression to a castration-resistance state is universal. Over the last decade new therapeutic targets for CRPC were identified, which raised the development of multiple new drugs. In 2010, the “Food and Drug Administration “ (FDA) approved the use of sipuleucel-T and cabazitaxel, in 2011 and 2012 abiraterone and enzalutamide respectively, were introduced for the treatment of metastatic CRPC. Denosumab and alpharadin were also approved for the prevention of skeleton related events in patients with bone metastasis, providing an alternative to zoledronic acid. With this article, the authors intend to conduct a systematic review of the latest clinical evidence and new approaches to CRPC© 2014 Associação Portuguesa de Urologia. Published by Elsevier España, S.L.U. All rights reserved