Nonequivalent Response to Bromodomain-Targeting BET Inhibitors in Oligodendrocyte Cell Fate Decision

The tandem bromodomains (BD1 and BD2) of the BET family proteins BRD2, BRD3, BRD4, and BRDT are structurally conserved but not functionally equivalent. In this issue of Chemistry & Biology, Gacias and colleagues report that a BD1-specific chemical inhibitor, Olinone, enhances oligodendrocyte differentiation, contrasting the reverse process triggered by broad BD1/BD2-targeting inhibitors, highlighting distinct roles of BD1 and BD2 in cell fate decision