AbstractPatterns of transcription factor expression establish a blueprint for the vertebrate forebrain early in embryogenesis. In the future diencephalon, several genes with patterned expression have been identified, yet their specific functions and interactions between them are not well understood. We have uncovered a crucial role for one such gene, zic2a, during formation of the anterior diencephalon in zebrafish. We show that zic2a is required for transcription of the prethalamic markers arx and dlx2a. This function is required during early steps of prethalamic development, soon after its specification. zic genes are evolutionarily related to glis, transcription factors that mediate hedgehog signaling. Intriguingly, the hedgehog signalin...
During neurulation, vertebrate embryos form a neural tube (NT), the rudiment of the central nervous ...
AbstractThe role of Zic1 was investigated by altering its expression status in developing spinal cor...
AbstractIn zebrafish, as in other vertebrates, the secreted signalling molecule Sonic hedgehog (Shh)...
AbstractPatterns of transcription factor expression establish a blueprint for the vertebrate forebra...
The Hedgehog (Hh) signaling pathway plays a crucial role in modulating embryonic development. Malfu...
Midway between the anterior neural border and the midbrain-hindbrain boundary, two well-known local ...
Here we report the expression of the zebrafish zic1 gene, also known as opl, a homologue to other ve...
AbstractIdentification of the earliest forebrain-specific markers should facilitate the elucidation ...
AbstractHoloprosencephaly (HPE), the most common malformation of the human forebrain, is associated ...
<div><p>Zic3 regulates early embryonic patterning in vertebrates. Loss of Zic3 function is known to ...
Identifcation of the earliest forebrain-specific markers should facilitate the elucidation of molecu...
The neuroectoderm arises during gastrulation as a population of undifferentiated proliferating neuro...
AbstractThe Gli family of zinc-finger transcription factors mediates Hedgehog (Hh) signaling in all ...
AbstractDuring development, the lumen of the neural tube develops into a system of brain cavities or...
12 p.This project aims to further our understanding of developmental genetics by identifying unknown...
During neurulation, vertebrate embryos form a neural tube (NT), the rudiment of the central nervous ...
AbstractThe role of Zic1 was investigated by altering its expression status in developing spinal cor...
AbstractIn zebrafish, as in other vertebrates, the secreted signalling molecule Sonic hedgehog (Shh)...
AbstractPatterns of transcription factor expression establish a blueprint for the vertebrate forebra...
The Hedgehog (Hh) signaling pathway plays a crucial role in modulating embryonic development. Malfu...
Midway between the anterior neural border and the midbrain-hindbrain boundary, two well-known local ...
Here we report the expression of the zebrafish zic1 gene, also known as opl, a homologue to other ve...
AbstractIdentification of the earliest forebrain-specific markers should facilitate the elucidation ...
AbstractHoloprosencephaly (HPE), the most common malformation of the human forebrain, is associated ...
<div><p>Zic3 regulates early embryonic patterning in vertebrates. Loss of Zic3 function is known to ...
Identifcation of the earliest forebrain-specific markers should facilitate the elucidation of molecu...
The neuroectoderm arises during gastrulation as a population of undifferentiated proliferating neuro...
AbstractThe Gli family of zinc-finger transcription factors mediates Hedgehog (Hh) signaling in all ...
AbstractDuring development, the lumen of the neural tube develops into a system of brain cavities or...
12 p.This project aims to further our understanding of developmental genetics by identifying unknown...
During neurulation, vertebrate embryos form a neural tube (NT), the rudiment of the central nervous ...
AbstractThe role of Zic1 was investigated by altering its expression status in developing spinal cor...
AbstractIn zebrafish, as in other vertebrates, the secreted signalling molecule Sonic hedgehog (Shh)...