Mammalian epidermis displays a characteristic calcium gradient, with low calcium levels in the lower, basal, and spinous epidermal layers, whereas calcium levels increase progressively towards the outer stratum granulosum, and declining again in the stratum corneum. As the calcium gradient disappears after acute permeability barrier disruption, and returns after 6 h in parallel with barrier recovery, barrier function (through restriction of transcutaneous water movement) could regulate the formation of the epidermal calcium gradient. Two types of experiments confirmed the role of barrier status in regulating the calcium gradient: (i) either a vapor-permeable membrane (Gore-Tex®) or an emollient (Vaseline®), applied after acute barrier disru...
Background/purpose: Calcium regulates the proliferation and differentiation of keratinocytes and pla...
Mammalian epidermis normally displays a distinctive calcium gradient, with low levels in the basal/s...
Several signals have been suggested in maintaining skin barrier homeostasis, but epidermal calcium i...
Mammalian epidermis normally displays a distinctive calcium gradient, with low levels in the basal/s...
Disruption of the epidermal permeability barrier causes an immediate loss of the calcium gradient, a...
Disruption of the epidermal permeability barrier causes an immediate loss of the calcium gradient, a...
Disruption of the epidermal permeability barrier causes an immediate loss of the calcium gradient, a...
The epidermal permeability barrier is established late in fetal development. Indeed, the Ca(2+) grad...
The epidemal permeability barrier forms late in gestation, coincident with decreased lipid synthesis...
Background/purpose: Calcium regulates the proliferation and differentiation of keratinocytes and pl...
The skin shows an important “epidermal permeability barrier homeostasis” in response to barrier disr...
Background/purpose: Calcium regulates the proliferation and differentiation of keratinocytes and pla...
Background/purpose: Calcium regulates the proliferation and differentiation of keratinocytes and pla...
Background/purpose: Calcium regulates the proliferation and differentiation of keratinocytes and pla...
Background/purpose: Calcium regulates the proliferation and differentiation of keratinocytes and pla...
Background/purpose: Calcium regulates the proliferation and differentiation of keratinocytes and pla...
Mammalian epidermis normally displays a distinctive calcium gradient, with low levels in the basal/s...
Several signals have been suggested in maintaining skin barrier homeostasis, but epidermal calcium i...
Mammalian epidermis normally displays a distinctive calcium gradient, with low levels in the basal/s...
Disruption of the epidermal permeability barrier causes an immediate loss of the calcium gradient, a...
Disruption of the epidermal permeability barrier causes an immediate loss of the calcium gradient, a...
Disruption of the epidermal permeability barrier causes an immediate loss of the calcium gradient, a...
The epidermal permeability barrier is established late in fetal development. Indeed, the Ca(2+) grad...
The epidemal permeability barrier forms late in gestation, coincident with decreased lipid synthesis...
Background/purpose: Calcium regulates the proliferation and differentiation of keratinocytes and pl...
The skin shows an important “epidermal permeability barrier homeostasis” in response to barrier disr...
Background/purpose: Calcium regulates the proliferation and differentiation of keratinocytes and pla...
Background/purpose: Calcium regulates the proliferation and differentiation of keratinocytes and pla...
Background/purpose: Calcium regulates the proliferation and differentiation of keratinocytes and pla...
Background/purpose: Calcium regulates the proliferation and differentiation of keratinocytes and pla...
Background/purpose: Calcium regulates the proliferation and differentiation of keratinocytes and pla...
Mammalian epidermis normally displays a distinctive calcium gradient, with low levels in the basal/s...
Several signals have been suggested in maintaining skin barrier homeostasis, but epidermal calcium i...