Nanoencapsulation of hydrophobic phytochemicals using poly (dl-lactide-co-glycolide) (PLGA) for antioxidant and antimicrobial delivery applications: Guabiroba fruit (Campomanesia xanthocarpa O. Berg) study

AbstractPrevious studies have reported antioxidant and antimicrobial activity of guabiroba extract (GE), which is associated to its polyphenolic and carotenoid contents. Encapsulation using polymeric materials could improve GE application, bioavailability, and stability in foods and pharmaceuticals. Poly (dl-lactide-co-glycolide) (PLGA) nanoparticles with entrapped GE were synthesized using the emulsion-evaporation method with different lactide to glycolide (50:50 and 65:35) ratios to determine the dependency of polymer composition on nanoparticles antioxidant and antimicrobial activities. Controlled release experiments showed an initial burst followed by a slower release rate of carotenoids inside PLGA matrix. Both nanoparticles showed Listeria innocua growth inhibition within the concentration range tested (