AbstractADP-ribosylation of proteins by the enzymatic transfer of ADP-ribose from NAD has been implicated in a number of biological processes. We report that inhibitors of ADP-ribosylation, most notably the novel inhibitor of arginine specific cellular mono(ADP-ribosyl) transferase, meta-iodobenzylguanidine (MIBG) as well as nicotinamide, l-arginine methyl ester (LAME) and guanyltyramine, inhibit histamine-induced endothelial production of inositol phosphates, release of arachidonic acid and production of prostacyclin (PGI2). Those same responses were unaffected by MIBG when triggered by thrombin or leukotriene C4. These findings suggest that ADP-ribosylation serves a role in histamine-induced production of prostacyclin and imply difference...
A549, a type II alveolar epithelial cell line stimulated with LPS (10 mug/ml), released high levels ...
Mono ADP-ribosylation is catalyzed by ADP-ribosyltransferases (mADPRTs) that transfer a single resi...
The ADP-ribosylation of proteins is a phylogenetically ancient mechanism that involves the transfer ...
AbstractADP-ribosylation of proteins by the enzymatic transfer of ADP-ribose from NAD has been impli...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
Nicotinamide Adenine Dinucleotide (NAD+) is mainly known as coenzyme of redox reactions for energy ...
Mono-ADP-ribosylation is a post-translational modification of cellular proteins that has been implic...
NAD:arginine mono-ADP-ribosyltransferases catalyze the transfer of ADP-ribose from NAD to the guanid...
ADP-ribosylation, a modification of proteins, nucleic acids and metabolites, confers broad functions...
A key process in the regulation of protein activities and thus cellular signaling pathways is the mo...
LL-37 is a cationic peptide belonging to the cathelicidin family that has antimicrobial and immune-m...
ADP-ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad function...
Nicotinamide Adenine Dinucleotide (NAD+) is mainly known as coenzyme of redox reactions for energy ...
Protein post-translational modifications (PTMs) are important for regulating protein function. One s...
ADP-ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad function...
A549, a type II alveolar epithelial cell line stimulated with LPS (10 mug/ml), released high levels ...
Mono ADP-ribosylation is catalyzed by ADP-ribosyltransferases (mADPRTs) that transfer a single resi...
The ADP-ribosylation of proteins is a phylogenetically ancient mechanism that involves the transfer ...
AbstractADP-ribosylation of proteins by the enzymatic transfer of ADP-ribose from NAD has been impli...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
Nicotinamide Adenine Dinucleotide (NAD+) is mainly known as coenzyme of redox reactions for energy ...
Mono-ADP-ribosylation is a post-translational modification of cellular proteins that has been implic...
NAD:arginine mono-ADP-ribosyltransferases catalyze the transfer of ADP-ribose from NAD to the guanid...
ADP-ribosylation, a modification of proteins, nucleic acids and metabolites, confers broad functions...
A key process in the regulation of protein activities and thus cellular signaling pathways is the mo...
LL-37 is a cationic peptide belonging to the cathelicidin family that has antimicrobial and immune-m...
ADP-ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad function...
Nicotinamide Adenine Dinucleotide (NAD+) is mainly known as coenzyme of redox reactions for energy ...
Protein post-translational modifications (PTMs) are important for regulating protein function. One s...
ADP-ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad function...
A549, a type II alveolar epithelial cell line stimulated with LPS (10 mug/ml), released high levels ...
Mono ADP-ribosylation is catalyzed by ADP-ribosyltransferases (mADPRTs) that transfer a single resi...
The ADP-ribosylation of proteins is a phylogenetically ancient mechanism that involves the transfer ...