Localization of Elevated Transforming Growth Factor-Alpha in Psoriatic Epidermis
- Turbitt, Marlyn L
- Akhurst, Rosemary J
- White, Stephen I
- MacKie, Rona M
Publication date
August 1990
DOI Publisher
The Society for Investigative Dermatology, Inc. Published by Elsevier Inc. ISSN
0022-202X Citation count (estimate)
50Abstract
Biopsies of involved and uninvolved skin from five patients with plaque psoriasis and normal skin from four healthy volunteers were investigated for steady-state quantities of TGF-alpha RNA and protein by in situ hybridization and immunohistochemistry. Increased levels of TGF-alpha RNA were found only in the high-level keratinocytes of involved psoriatic skin (p <0.001). Elevated levels of TGF-alpha protein were seen in both the high-level and basal layers of involved psoriatic skin compared to uninvolved psoriatic and normal control skin. Elevated TGF-alpha gene expression is thus implicated in the hyperproliferation of keratinocytes and possibly the altered maturation pattern seen in psoriasis
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