A wasp venom mastoparan-induced polyphosphoinositide breakdown in rat peritoneal mast cells
- Okano, Yukio
- Takagi, Hajime
- Tohmatsu, Toyohiko
- Nakashima, Shigeru
- Kuroda, Yoichiro
- Saito, Kazuki
- Nozawa, Yoshinori
Publication date
September 1985
DOI Publisher
Published by Elsevier B.V. ISSN
0014-5793 Citation count (estimate)
58Abstract
AbstractThe phospholipid metabolism of rat peritoneal mast cells stimulated with mastoparan, a secretagogue purified from wasp venom, was investigated. Mastoparan at 20 μgml caused a rapid secretion of histamine. Mastoparan induced a transient decrease of phosphatidylinositol 4,5-bisphosphate on 32P labeling and generation of a water-soluble degradation product, inositol trisphosphate on [3H]inositol labeling, suggesting the activation of phospholipase C upon stimulation
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