Associations between changes in ferritin levels and susceptibility-weighted imaging filtered phase in patients with relapsing–remitting multiple sclerosis over 24weeks of therapy with subcutaneous interferon beta-1a three times weekly
- Dwyer, Michael G.
- Zivadinov, Robert
- Markovic-Plese, Silva
- Bergsland, Niels
- Heininen-Brown, Mari
- Carl, Ellen
- Kennedy, Cheryl
- Weinstock-Guttman, Bianca
- Hayward, Brooke
- Dangond, Fernando
Publication date
April 2015
DOI Publisher
Elsevier B.V. ISSN
0165-5728 Citation count (estimate)
1Abstract
AbstractSubanalysis of a pilot study (NCT01085318) assessed correlations between serum ferritin and imaging assessments in relapsing–remitting multiple sclerosis patients (n=23) receiving 44μg interferon beta-1a subcutaneously three times weekly. At baseline, 12, and 24weeks, mean ferritin was 75, 127 (p<0.001 vs baseline), and 101 (p=0.020 vs baseline) ng/mL. No relationship between ferritin and susceptibility-weighted imaging (SWI)-filtered phase of subcortical deep gray matter was found. Increasing ferritin correlated with decreasing lesion numbers on both fluid attenuated inversion recovery and SWI phase at 12weeks (r=−0.62; p=0.003; n=21), and with decreasing gadolinium-enhancing lesion volume at 24weeks (r=−0.71; p=0.050; n=8)
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