Increase of β-actin mRNA upon hypotonic perfusion of perfused rat liver

  • Schulz, Wolfgang A.
  • Eickelmann, Peter
  • Hallbrucker, Christian
  • Sies, Helmut
  • Ha¨ussinger, Dieter
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Publication date
November 1991
Publisher
Federation of European Biochemical Societies. Published by Elsevier B.V.

Abstract

Abstractβ-Actin mRNA levels in livers exposed to hypotonic perfusion (from 305 to 225 mosmol/1) for one hour are increased 2-fold relative to albumin mRNA. Like albumin, glyceraldehyde-3-phosphate dehydrogenase and tyrosine aminotransferase mRNAs remain at the levels observed under normotonic conditions. The increase in β-actin mRNA is interpreted as a cytoskeletal response due to cell swelling

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