Targeting a specific arm of signaling pathways is of great interest. In this issue of Chemistry & Biology, Bosco et al. exploit the interactive interface between Rac GTPase and its effector p67phox to specifically inhibit reactive oxygen species production without perturbing other Rac-mediated cellular processes
Oxidants are produced in physiological and pathological conditions. The production of reactive nitro...
SummaryThe Rac GTPase regulates Rho signaling in a broad range of physiological settings and in onco...
BackgroundRho family GTPases are critical regulators of the cytoskeleton and affect cell migration, ...
Targeting a specific arm of signaling pathways is of great interest. In this issue of Chemistry & Bi...
SummaryThe NADPH oxidase enzyme complex, NOX2, is responsible for reactive oxygen species production...
Precise spatiotemporal regulation of O2 --generating NADPH oxidases (Nox) is a vital requirement. In...
Rho GTPases regulate multiple cellular processes including actin cytoskeletal rearrangements, transc...
Signaling through the Rho family of small GTPases has been increasingly investigated for their invol...
Transient expression of constitutively active Rac1 derivatives, (G12V) or (Q61L), was sufficient to ...
There is now considerable experimental evidence that aberrant activation of Rho family small GTPases...
The RAC small GTPases are molecular switches that when active, signal multiple cellular processes in...
AbstractThe NADPH oxidase of phagocytes is essential for defence against invading microorganisms. Th...
The small GTPases of the Rho family regulate many aspects of actin dynamics, but are functionally co...
International audienceThe low molecular weight GTP binding protein Rac is essential to the activatio...
The Rho family GTPase Rac acts as a molecular switch for signal transduction to regulate various cel...
Oxidants are produced in physiological and pathological conditions. The production of reactive nitro...
SummaryThe Rac GTPase regulates Rho signaling in a broad range of physiological settings and in onco...
BackgroundRho family GTPases are critical regulators of the cytoskeleton and affect cell migration, ...
Targeting a specific arm of signaling pathways is of great interest. In this issue of Chemistry & Bi...
SummaryThe NADPH oxidase enzyme complex, NOX2, is responsible for reactive oxygen species production...
Precise spatiotemporal regulation of O2 --generating NADPH oxidases (Nox) is a vital requirement. In...
Rho GTPases regulate multiple cellular processes including actin cytoskeletal rearrangements, transc...
Signaling through the Rho family of small GTPases has been increasingly investigated for their invol...
Transient expression of constitutively active Rac1 derivatives, (G12V) or (Q61L), was sufficient to ...
There is now considerable experimental evidence that aberrant activation of Rho family small GTPases...
The RAC small GTPases are molecular switches that when active, signal multiple cellular processes in...
AbstractThe NADPH oxidase of phagocytes is essential for defence against invading microorganisms. Th...
The small GTPases of the Rho family regulate many aspects of actin dynamics, but are functionally co...
International audienceThe low molecular weight GTP binding protein Rac is essential to the activatio...
The Rho family GTPase Rac acts as a molecular switch for signal transduction to regulate various cel...
Oxidants are produced in physiological and pathological conditions. The production of reactive nitro...
SummaryThe Rac GTPase regulates Rho signaling in a broad range of physiological settings and in onco...
BackgroundRho family GTPases are critical regulators of the cytoskeleton and affect cell migration, ...
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