SummaryThe cellular mechanisms that regulate the maintenance of adult tissue stem cells are still largely unknown. We show here that the p53 family member, TAp63, is essential for maintenance of epidermal and dermal precursors and that, in its absence, these precursors senesce and skin ages prematurely. Specifically, we have developed a TAp63 conditional knockout mouse and used it to ablate TAp63 in the germline (TAp63−/−) or in K14-expressing cells in the basal layer of the epidermis (TAp63fl/fl;K14cre+). TAp63−/− mice age prematurely and develop blisters, skin ulcerations, senescence of hair follicle-associated dermal and epidermal cells, and decreased hair morphogenesis. These phenotypes are likely due to loss of TAp63 in dermal and epid...
The transcription factor p63 is essential for the formation of the epidermis and other stratifying e...
Heterozygous germline mutations in p63, a transcription factor of the p53 family, result in abnormal...
Epidermal development requires the transcription factor p63, as p63-/- mice are born dead, without s...
The cellular mechanisms that regulate the maintenance of adult tissue stem cells are still largely u...
SummaryThe cellular mechanisms that regulate the maintenance of adult tissue stem cells are still la...
The p53 family member p63 comprises multiple isoforms and is critical for stratified epithelial deve...
SummaryThe p53 homolog p63 is essential for development, yet its role in cancer is not clear. We dis...
The p53 tumor suppressor plays a key role in organismal aging. A cellular mechanism postulated to dr...
SummaryThe distinguishing feature of adult stem cells is their extraordinary capacity to divide prio...
Deficiency of p63, a p53-related protein, causes severe defects in epithelial morphogenesis. Studies...
AbstractThe p53 transcription factor is activated by various types of cell stress or DNA damage and ...
The skin is composed of two major compartments, the dermis and epidermis. The epidermis forms a barr...
SummaryIncreasing evidence suggests that deficits in adult stem cell maintenance cause aberrant tiss...
p63 is distinct from its homologue p53 in that its role as a tumour suppressor is controversial, an ...
The p53-related transcription factor p63 is critically important for basic cellular functions during...
The transcription factor p63 is essential for the formation of the epidermis and other stratifying e...
Heterozygous germline mutations in p63, a transcription factor of the p53 family, result in abnormal...
Epidermal development requires the transcription factor p63, as p63-/- mice are born dead, without s...
The cellular mechanisms that regulate the maintenance of adult tissue stem cells are still largely u...
SummaryThe cellular mechanisms that regulate the maintenance of adult tissue stem cells are still la...
The p53 family member p63 comprises multiple isoforms and is critical for stratified epithelial deve...
SummaryThe p53 homolog p63 is essential for development, yet its role in cancer is not clear. We dis...
The p53 tumor suppressor plays a key role in organismal aging. A cellular mechanism postulated to dr...
SummaryThe distinguishing feature of adult stem cells is their extraordinary capacity to divide prio...
Deficiency of p63, a p53-related protein, causes severe defects in epithelial morphogenesis. Studies...
AbstractThe p53 transcription factor is activated by various types of cell stress or DNA damage and ...
The skin is composed of two major compartments, the dermis and epidermis. The epidermis forms a barr...
SummaryIncreasing evidence suggests that deficits in adult stem cell maintenance cause aberrant tiss...
p63 is distinct from its homologue p53 in that its role as a tumour suppressor is controversial, an ...
The p53-related transcription factor p63 is critically important for basic cellular functions during...
The transcription factor p63 is essential for the formation of the epidermis and other stratifying e...
Heterozygous germline mutations in p63, a transcription factor of the p53 family, result in abnormal...
Epidermal development requires the transcription factor p63, as p63-/- mice are born dead, without s...