AbstractThe microenvironment between the plasma membrane and the near-membrane sarcoplasmic reticulum (SR) may play an important role in Ca2+ regulation in smooth muscle cells. We used a three-dimensional mathematical model of Ca2+ diffusion and regulation and experimental measurements of SR Ca2+ uptake and the distribution of the SR in isolated smooth muscle cells to predict the extent that the near-membrane SR could load Ca2+ after the opening of single plasma membrane Ca2+ channels. We also modeled the effect of SR uptake on 1), single-channel Ca2+ transients in the near-membrane space; 2), the association of Ca2+ with Ca2+ buffers in this space; and 3), the amount of Ca2+ reaching the central cytoplasm of the cell. Our results indicate ...
The sarcoplasmic reticulum (SR) and apposed regions of the sarcolemma passively trap Ca2+ entering t...
In smooth muscle, Ca2+ regulates cell division, growth and cell death as well as providing the main ...
AbstractThapsigargin-sensitive sarco/endoplasmic reticulum Ca2+ pumps (SERCAs) are involved in maint...
Although many of the processes involved in the regulation of Ca2+ in smooth muscle have been studied...
In smooth muscle, Ca2+ controls diverse activities including cell division, contraction and cell dea...
AbstractDespite the fact that Ca2+ transport into the sarcoplasmic reticulum (SR) of muscle cells is...
In vascular smooth muscle cells, Ca2+ release via IP3 receptors (IP3R) and ryanodine receptors (RyR)...
Features of Ca2+ signals including the amplitude, duration, frequency and location are encoded by v...
<div><p>Variations of free calcium concentration ([Ca<sup>2+</sup>]) are powerful intracellular sign...
Agonist-stimulated waves of elevated cytoplasmic Ca2+ concentration ([Ca2+]i ) regulate blood vessel...
The sarcoplasmic reticulum (SR) of skeletal muscle is an intracellular membraneous network that, thr...
Variations of free calcium concentration ([Ca2+]) are powerful intracellular signals, controlling co...
Contraction of vascular smooth muscle (VSM) is regulated by fluctuations in the intracellular concen...
The role of sarcoplasmic reticulum (SR) in vascular smooth muscle was evaluated with respect to regu...
In smooth muscle mitochondria are major regulators of contractility, proliferation and growth throug...
The sarcoplasmic reticulum (SR) and apposed regions of the sarcolemma passively trap Ca2+ entering t...
In smooth muscle, Ca2+ regulates cell division, growth and cell death as well as providing the main ...
AbstractThapsigargin-sensitive sarco/endoplasmic reticulum Ca2+ pumps (SERCAs) are involved in maint...
Although many of the processes involved in the regulation of Ca2+ in smooth muscle have been studied...
In smooth muscle, Ca2+ controls diverse activities including cell division, contraction and cell dea...
AbstractDespite the fact that Ca2+ transport into the sarcoplasmic reticulum (SR) of muscle cells is...
In vascular smooth muscle cells, Ca2+ release via IP3 receptors (IP3R) and ryanodine receptors (RyR)...
Features of Ca2+ signals including the amplitude, duration, frequency and location are encoded by v...
<div><p>Variations of free calcium concentration ([Ca<sup>2+</sup>]) are powerful intracellular sign...
Agonist-stimulated waves of elevated cytoplasmic Ca2+ concentration ([Ca2+]i ) regulate blood vessel...
The sarcoplasmic reticulum (SR) of skeletal muscle is an intracellular membraneous network that, thr...
Variations of free calcium concentration ([Ca2+]) are powerful intracellular signals, controlling co...
Contraction of vascular smooth muscle (VSM) is regulated by fluctuations in the intracellular concen...
The role of sarcoplasmic reticulum (SR) in vascular smooth muscle was evaluated with respect to regu...
In smooth muscle mitochondria are major regulators of contractility, proliferation and growth throug...
The sarcoplasmic reticulum (SR) and apposed regions of the sarcolemma passively trap Ca2+ entering t...
In smooth muscle, Ca2+ regulates cell division, growth and cell death as well as providing the main ...
AbstractThapsigargin-sensitive sarco/endoplasmic reticulum Ca2+ pumps (SERCAs) are involved in maint...