Highly conserved influenza A virus epitope sequences as candidates of H3N2 flu vaccine targets
- Wu, Ko-Wen
- Chien, Chih-Yi
- Li, Shiao-Wen
- King, Chwan-Chuen
- Chang, Chuan-Hsiung
DOIAbstract
AbstractThis study focused on identifying the conserved epitopes in a single subtype A (H3N2)—as candidates for vaccine targets. We identified a total of 32 conserved epitopes in four viral proteins [22 HA, 4PB1, 3 NA, 3 NP]. Evaluation of conserved epitopes in coverage during 1968–2010 revealed that (1) 12 HA conserved epitopes were highly present in the circulating viruses; (2) the remaining 10 HA conserved epitopes appeared with lower percentage but a significantly increasing trend after 1989 [p<0.001]; and (3) the conserved epitopes in NA, NP and PB1 are also highly frequent in wild-type viruses. These conserved epitopes also covered an extremely high percentage of the 16 vaccine strains during the 42year period. The identification of h...
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