AbstractThere are 80 spikes on the surface of Sindbis virus arranged as an icosahedral surface lattice. Each spike consists of three copies of each of the glycoproteins E1 and E2. There are two glycosylation sites on E1 and two on E2. These four sites have been located by removal of the glycosylation recognition motifs using site-specific mutagenesis, followed by cryoelectron microscopy. The positions of these sites have demonstrated that E2 forms the protruding spikes and that E1 must be long and narrow, lying flat on the viral surface, forming an icosahedral scaffold analogous to the arrangement of the E glycoprotein in flaviviruses. This arrangement of E1 leads to both dimeric and trimeric intermolecular contacts, consistent with the obs...
AbstractAlphaviruses are isometric enveloped viruses approximately 70 nm in diameter. The viral surf...
AbstractSindbis virus is a complex aggregate of RNA, protein and lipid. The virus is organized as tw...
We have studied interactions between nucleocapsids and glycoproteins required for budding of alphavi...
AbstractThere are 80 spikes on the surface of Sindbis virus arranged as an icosahedral surface latti...
SummaryThe 9 Å resolution cryo-electron microscopy map of Sindbis virus presented here provides stru...
The 9 Å resolution cryo-electron microscopy map of Sindbis virus presented here provides structural ...
AbstractSindbis is an Alphavirus capable of infecting and replicating in both vertebrate and inverte...
AbstractThe glycoprotein envelope of alphaviruses consists of two proteins, E1 and E2. E1 is respons...
AbstractSindbis virus particles are composed of three structural proteins (Capsid/E2/E1). In the mat...
AbstractBackground: Many enveloped viruses exit cells by budding from the plasma membrane. The drivi...
AbstractAssembly and budding of alphaviruses are postulated to occur by protein–protein interactions...
Cross-species viral transmission subjects parent and progeny alphaviruses to differential post-trans...
AbstractAlphaviruses are a group of icosahedral, positive-strand RNA, enveloped viruses. The membran...
AbstractThe two glycoproteins that form the external spikes of the alphaviruses are type 1 membrane ...
Cross-species viral transmission subjects parent and progeny alphaviruses to differential post-trans...
AbstractAlphaviruses are isometric enveloped viruses approximately 70 nm in diameter. The viral surf...
AbstractSindbis virus is a complex aggregate of RNA, protein and lipid. The virus is organized as tw...
We have studied interactions between nucleocapsids and glycoproteins required for budding of alphavi...
AbstractThere are 80 spikes on the surface of Sindbis virus arranged as an icosahedral surface latti...
SummaryThe 9 Å resolution cryo-electron microscopy map of Sindbis virus presented here provides stru...
The 9 Å resolution cryo-electron microscopy map of Sindbis virus presented here provides structural ...
AbstractSindbis is an Alphavirus capable of infecting and replicating in both vertebrate and inverte...
AbstractThe glycoprotein envelope of alphaviruses consists of two proteins, E1 and E2. E1 is respons...
AbstractSindbis virus particles are composed of three structural proteins (Capsid/E2/E1). In the mat...
AbstractBackground: Many enveloped viruses exit cells by budding from the plasma membrane. The drivi...
AbstractAssembly and budding of alphaviruses are postulated to occur by protein–protein interactions...
Cross-species viral transmission subjects parent and progeny alphaviruses to differential post-trans...
AbstractAlphaviruses are a group of icosahedral, positive-strand RNA, enveloped viruses. The membran...
AbstractThe two glycoproteins that form the external spikes of the alphaviruses are type 1 membrane ...
Cross-species viral transmission subjects parent and progeny alphaviruses to differential post-trans...
AbstractAlphaviruses are isometric enveloped viruses approximately 70 nm in diameter. The viral surf...
AbstractSindbis virus is a complex aggregate of RNA, protein and lipid. The virus is organized as tw...
We have studied interactions between nucleocapsids and glycoproteins required for budding of alphavi...