Effects of pacing-induced and balloon coronary occlusion ischemia on left atrial function in patients with coronary artery disease

AbstractOBJECTIVESThe aim of this study was to compare left atrial (LA) function in 16 patients with distal left anterior descending (LAD) and in 16 patients with proximal left circumflex (LCx) coronary artery stenosis at rest and immediately after pacing-induced tachycardia (LAD-pacing [P] and LCx-P) or coronary occlusion (LAD-CO and LCx-CO).BACKGROUNDDuring left ventricular (LV) ischemia, compensatory augmentation of LA contraction enhances LV filling and performance. The left atrium is supplied predominantly by branches arising from the LCx. Therefore, we hypothesized that one mechanism for the loss of atrial contraction may be ischemic LA dysfunction.METHODSLeft ventricular and LA pressure–area relations were derived from simultaneous double-tip micromanometer pressure recordings and automatic boundary detection echocardiograms.RESULTSImmediately after pacing or after coronary occlusion, LV end-diastolic pressure, LV relaxation, LA mean pressure and LV stiffness significantly increased in all patients. However, the area of the A loop of the LA pressure–area relation, representing the LA pump function, significantly decreased in groups LCx-P and LCx-CO (from 14 ± 3 to 9 ± 2, and from 16 ± 4 to 9 ± 2 mm Hg·cm2, respectively, p < 0.05), whereas it increased in groups LAD-P and LAD-CO (from 12 ± 3 to 54 ± 10, and from 16 ± 3 to 49 ± 8 mm Hg·cm2, respectively, p < 0.001).CONCLUSIONSIn patients with LAD stenosis, LV supply or demand ischemia is associated with enhanced LA pump function. However, in patients with proximal LCx stenosis who develop the same type and degree of ischemia, LA branches might have been affected, rendering the LA ischemic and unable to increase its booster pump function