New potent inhibitors of angiotensin converting enzyme
- Attwood, Michael R.
- Francis, R.John
- Hassall, Cedric H.
- Kröhn, Antonin
- Lawton, Geoffrey
- Natoff, Ian L.
- Nixon, John S.
- Redshaw, Sally
- Thomas, W.Anthony
Publication date
January 1984
DOI Publisher
Published by Elsevier B.V. ISSN
0014-5793 Citation count (estimate)
48Abstract
AbstractUsing an earlier model of the favoured orientation of binding functions of angiotensin converting enzyme (ACE) inhibitors, it has been possible to postulate a new, 7,6-bicyclic system, based on hexahydropyridazine, which might be expected to have high potency. Some members of this system which have been synthesised have been shown to be very active ACE inhibitors, in vitro and in vivo
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