AbstractTie1 is a receptor tyrosine kinase with broad expression in embryonic endothelium. Reduction of Tie1 levels in mouse embryos with a hypomorphic Tie1 allele resulted in abnormal lymphatic patterning and architecture, decreased lymphatic draining efficiency, and ultimately, embryonic demise. Here we report that Tie1 is present uniformly throughout the lymphatics and from late embryonic/early postnatal stages, becomes more restricted to lymphatic valve regions. To investigate later events of lymphatic development, we employed Cre-loxP recombination utilizing a floxed Tie1 allele and an Nfatc1Cre line, to provide loxP excision predominantly in lymphatic endothelium and developing valves. Interestingly, unlike the early prenatal defects ...
Endothelial cells of initial lymphatics have discontinuous button-like junctions (buttons), unlike c...
Primitive lymphatic vessels are remodeled into functionally specialized initial and collecting lymph...
AbstractDuring embryogenesis, lymphatic endothelial progenitor cells first arise from a subset of bl...
AbstractTie1 is a receptor tyrosine kinase with broad expression in embryonic endothelium. Reduction...
AbstractThe lack of specific markers has raised problems in documenting the precise manner by which ...
AbstractConnexins (Cxs), proteins that are vital for intercellular communication in vertebrates, hav...
AbstractLymph is returned to the blood circulation exclusively via four lymphovenous valves (LVVs). ...
Collecting lymphatic ducts contain intraluminal valves that prevent backflow. In mice, lymphatic val...
The lymphatic system is composed of a hierarchical network of fluid absorbing lymphatic capillaries ...
BACKGROUND: In vivo studies demonstrate that the Prox1 transcription factor plays a critical role in...
SummaryLymphatic valves are essential for efficient lymphatic transport, but the mechanisms of early...
Recently, substantial advances have been made in understanding the formation and remodeling of the l...
Lymphatic valves (LVs) are cusped luminal structures that permit the movement of lymph in only one d...
AbstractMaintenance of tissue homeostasis and immune surveillance are important functions of the lym...
Blood vessels and lymphatic vessels are functionally and molecularly distinct. Blood vessels carry r...
Endothelial cells of initial lymphatics have discontinuous button-like junctions (buttons), unlike c...
Primitive lymphatic vessels are remodeled into functionally specialized initial and collecting lymph...
AbstractDuring embryogenesis, lymphatic endothelial progenitor cells first arise from a subset of bl...
AbstractTie1 is a receptor tyrosine kinase with broad expression in embryonic endothelium. Reduction...
AbstractThe lack of specific markers has raised problems in documenting the precise manner by which ...
AbstractConnexins (Cxs), proteins that are vital for intercellular communication in vertebrates, hav...
AbstractLymph is returned to the blood circulation exclusively via four lymphovenous valves (LVVs). ...
Collecting lymphatic ducts contain intraluminal valves that prevent backflow. In mice, lymphatic val...
The lymphatic system is composed of a hierarchical network of fluid absorbing lymphatic capillaries ...
BACKGROUND: In vivo studies demonstrate that the Prox1 transcription factor plays a critical role in...
SummaryLymphatic valves are essential for efficient lymphatic transport, but the mechanisms of early...
Recently, substantial advances have been made in understanding the formation and remodeling of the l...
Lymphatic valves (LVs) are cusped luminal structures that permit the movement of lymph in only one d...
AbstractMaintenance of tissue homeostasis and immune surveillance are important functions of the lym...
Blood vessels and lymphatic vessels are functionally and molecularly distinct. Blood vessels carry r...
Endothelial cells of initial lymphatics have discontinuous button-like junctions (buttons), unlike c...
Primitive lymphatic vessels are remodeled into functionally specialized initial and collecting lymph...
AbstractDuring embryogenesis, lymphatic endothelial progenitor cells first arise from a subset of bl...