It has been assumed that cells distinguish viral from cellular DNA due to the former's presence in the cytosol. However, in this issue, Kerur et al. (2011) propose that the DNA genome of Kaposi's sarcoma-associated herpesvirus (KSHV) is recognized inside the nucleus by the DNA sensor IFI16, leading inflammasome activation
Herpesviruses are DNA viruses harboring the capacity to establish lifelong latent-recurrent infectio...
As a result of the ongoing virus-host arms race, viruses have evolved numerous immune subversion str...
Herpesviruses are DNA viruses harboring the capacity to establish lifelong latent-recurrent infectio...
It has been assumed that cells distinguish viral from cellular DNA due to the former's presence in t...
It has been assumed that cells distinguish viral from cellular DNA due to the former's presence in t...
SummaryInflammasomes are cytoplasmic sensors of foreign molecules, including pathogens, and function...
Sensing of invading DNA virus genomes appear to be triggered by a number of host cell DNA sensors de...
The innate immune system is important for control of infections, including herpesvirus infections. I...
<div><p>The innate immune system pattern recognition receptors (PRR) are the first line of host defe...
SummaryNuclear sensing of viral DNA has emerged as an essential step in innate immune responses agai...
The innate immune system is important for control of infections, including herpesvirus infections. I...
AbstractHerpes simplex virus (HSV) undergoes a lytic infection in epithelial cells and a latent infe...
<div><p>IFI16 (gamma-interferon-inducible protein 16), a predominantly nuclear protein involved in t...
<p>(<b>1</b>) Following viral entry, the nucleocapsid traffics to the nuclear pore region, linear DN...
Many human cells can sense the presence of exogenous DNA during infection though the cytosolic DNA r...
Herpesviruses are DNA viruses harboring the capacity to establish lifelong latent-recurrent infectio...
As a result of the ongoing virus-host arms race, viruses have evolved numerous immune subversion str...
Herpesviruses are DNA viruses harboring the capacity to establish lifelong latent-recurrent infectio...
It has been assumed that cells distinguish viral from cellular DNA due to the former's presence in t...
It has been assumed that cells distinguish viral from cellular DNA due to the former's presence in t...
SummaryInflammasomes are cytoplasmic sensors of foreign molecules, including pathogens, and function...
Sensing of invading DNA virus genomes appear to be triggered by a number of host cell DNA sensors de...
The innate immune system is important for control of infections, including herpesvirus infections. I...
<div><p>The innate immune system pattern recognition receptors (PRR) are the first line of host defe...
SummaryNuclear sensing of viral DNA has emerged as an essential step in innate immune responses agai...
The innate immune system is important for control of infections, including herpesvirus infections. I...
AbstractHerpes simplex virus (HSV) undergoes a lytic infection in epithelial cells and a latent infe...
<div><p>IFI16 (gamma-interferon-inducible protein 16), a predominantly nuclear protein involved in t...
<p>(<b>1</b>) Following viral entry, the nucleocapsid traffics to the nuclear pore region, linear DN...
Many human cells can sense the presence of exogenous DNA during infection though the cytosolic DNA r...
Herpesviruses are DNA viruses harboring the capacity to establish lifelong latent-recurrent infectio...
As a result of the ongoing virus-host arms race, viruses have evolved numerous immune subversion str...
Herpesviruses are DNA viruses harboring the capacity to establish lifelong latent-recurrent infectio...
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