SummaryOX40 is a T cell costimulator activated by OX40L. Blockade of the OX40L-OX40 interaction has ameliorative effects in animal models of T cell pathologies. In order to better understand the interaction between OX40 and OX40L, we have determined the crystal structure of murine OX40L and of the human OX40-OX40L complex at 1.45 and 2.4 Å, respectively. These structures show that OX40L is an unusually small member of the tumor necrosis factor superfamily (TNFSF). The arrangement of the OX40L protomers forming the functional trimer is atypical and differs from that of other members by a 15° rotation of each protomer with respect to the trimer axis, resulting in an open assembly. Site-directed changes of the interfacial residues of OX40L sug...
We have previously shown that OX40L/OX40 interaction is critical for TCR-independent selective proli...
Mycosis fungoides (MF) and Sézary syndrome (SS), the most common types of cutaneous T-cell lymphoma ...
We have previously shown that OX40L/OX40 interaction is critical for TCR-independent selective proli...
OX40 is a type 1 transmembrane glycoprotein, reported nearly 30 years ago as a cell surface antigen ...
OX40 ligand (OX40L) and OX40 are members of the tumor necrosis factor and tumor necrosis factor rece...
AbstractOX40 is a member of the TNF/NGF-receptor family expressed on activated T cells, whose ligand...
AbstractThe tumor necrosis factor family molecule Ox40-ligand (Ox40L) has been identified as a poten...
The OX40 receptor is preferentially expressed by T cells, and its cognate ligand OX40L is primarily ...
AbstractOX40, a member of the TNF receptor superfamily, is expressed on activated T cells and implic...
Body's defence mechanism has ability to combat tumour cells but tumour cells can circumvent immune s...
Agonistic antibodies targeting co-stimulating receptor OX40 on T cells are considered as important a...
The OX40 receptor is preferentially expressed by T cells, and its cognate ligand OX40L is primarily ...
AbstractOX40 is a member of the TNF/NGF-receptor family expressed on activated T cells, whose ligand...
Among the costimulatory members of the tumour necrosis factor superfamily, the OX40 molecule and its...
We have previously shown that OX40L/OX40 interaction is critical for TCR-independent selective proli...
We have previously shown that OX40L/OX40 interaction is critical for TCR-independent selective proli...
Mycosis fungoides (MF) and Sézary syndrome (SS), the most common types of cutaneous T-cell lymphoma ...
We have previously shown that OX40L/OX40 interaction is critical for TCR-independent selective proli...
OX40 is a type 1 transmembrane glycoprotein, reported nearly 30 years ago as a cell surface antigen ...
OX40 ligand (OX40L) and OX40 are members of the tumor necrosis factor and tumor necrosis factor rece...
AbstractOX40 is a member of the TNF/NGF-receptor family expressed on activated T cells, whose ligand...
AbstractThe tumor necrosis factor family molecule Ox40-ligand (Ox40L) has been identified as a poten...
The OX40 receptor is preferentially expressed by T cells, and its cognate ligand OX40L is primarily ...
AbstractOX40, a member of the TNF receptor superfamily, is expressed on activated T cells and implic...
Body's defence mechanism has ability to combat tumour cells but tumour cells can circumvent immune s...
Agonistic antibodies targeting co-stimulating receptor OX40 on T cells are considered as important a...
The OX40 receptor is preferentially expressed by T cells, and its cognate ligand OX40L is primarily ...
AbstractOX40 is a member of the TNF/NGF-receptor family expressed on activated T cells, whose ligand...
Among the costimulatory members of the tumour necrosis factor superfamily, the OX40 molecule and its...
We have previously shown that OX40L/OX40 interaction is critical for TCR-independent selective proli...
We have previously shown that OX40L/OX40 interaction is critical for TCR-independent selective proli...
Mycosis fungoides (MF) and Sézary syndrome (SS), the most common types of cutaneous T-cell lymphoma ...
We have previously shown that OX40L/OX40 interaction is critical for TCR-independent selective proli...