AbstractAbortive attempts at DNA repair can contribute to the effects of DNA damage inflicted by cytotoxic drugs. DNA methylation damage, 6-thioguanine and cisplatin adducts all owe their cytotoxicity in part to the intervention of DNA mismatch repair
Alkylating agents are a structurally diverse group of com-pounds that cause a wide range of biologic...
Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxi...
Purpose: DNA damage repair can lead to epigenetic changes. DNA mismatch repair proteins bind to plat...
AbstractAbortive attempts at DNA repair can contribute to the effects of DNA damage inflicted by cyt...
Methylating agents are widely used in chemotherapy and kill cancer cells by causing DNA dama...
Purpose: The mismatch repair (MMR) system plays a major role in mediating the cytotoxicity and clast...
Fifteen variants with >/=30-fold resistance to N-methyl-N-nitrosourea were isolated from the Burkitt...
The thiopurine 6-thioguanine (S6G) is used to treat acute leukaemia. Its cytotoxic effect requires a...
The cytotoxic effects of alkylating agents are strongly attenuated by cellular DNA repair processes,...
The toxic action of the anticancer drug thioguanine is believed to involve incorporation into DNA, m...
The genetic information encoded in genomes must be faithfully replicated and transmitted to daughter...
The DNA mismatch repair (MMR) system maintains genome integrity by correcting replication errors. MM...
AbstractBackground: The antitumor drug cis-diamminedichloroplatinum(II) (cis-DDP or cisplatin) exert...
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemistry, February 2002.Vita.Includ...
DNA repair deficiencies are common among cancer cells and represent a potential vulnerability that m...
Alkylating agents are a structurally diverse group of com-pounds that cause a wide range of biologic...
Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxi...
Purpose: DNA damage repair can lead to epigenetic changes. DNA mismatch repair proteins bind to plat...
AbstractAbortive attempts at DNA repair can contribute to the effects of DNA damage inflicted by cyt...
Methylating agents are widely used in chemotherapy and kill cancer cells by causing DNA dama...
Purpose: The mismatch repair (MMR) system plays a major role in mediating the cytotoxicity and clast...
Fifteen variants with >/=30-fold resistance to N-methyl-N-nitrosourea were isolated from the Burkitt...
The thiopurine 6-thioguanine (S6G) is used to treat acute leukaemia. Its cytotoxic effect requires a...
The cytotoxic effects of alkylating agents are strongly attenuated by cellular DNA repair processes,...
The toxic action of the anticancer drug thioguanine is believed to involve incorporation into DNA, m...
The genetic information encoded in genomes must be faithfully replicated and transmitted to daughter...
The DNA mismatch repair (MMR) system maintains genome integrity by correcting replication errors. MM...
AbstractBackground: The antitumor drug cis-diamminedichloroplatinum(II) (cis-DDP or cisplatin) exert...
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemistry, February 2002.Vita.Includ...
DNA repair deficiencies are common among cancer cells and represent a potential vulnerability that m...
Alkylating agents are a structurally diverse group of com-pounds that cause a wide range of biologic...
Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxi...
Purpose: DNA damage repair can lead to epigenetic changes. DNA mismatch repair proteins bind to plat...
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