Implications of Introducing High-Sensitivity Cardiac Troponin T Into Clinical Practice Data From the SWEDEHEART Registry

Melki, Dina
Lugnegård, Johan
Alfredsson, Joakim
Lind, Suzanne
Eggers, Kai M.
Lindahl, Bertil
Jernberg, Tomas

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Publication date

April 2015

DOI

10.1016/j.jacc.2015.02.044

Publisher

American College of Cardiology Foundation. Published by Elsevier Inc.

Abstract

AbstractBackgroundCardiac troponin is the preferred biomarker for diagnosing myocardial infarction (MI).ObjectivesThe aim of this study was to examine the implications of introducing high-sensitivity cardiac troponin T (hs-cTnT) into clinical practice and to define at what hs-cTnT level risk starts to increase.MethodsWe analyzed data from 48,594 patients admitted because of symptoms suggesting an acute coronary syndrome and who were entered into a large national registry. Patients were divided into Group 1, those with hs-cTnT <6 ng/l; Group 2, those with hs-cTnT 6 to 13 ng/l; Group 3, those with hs-cTnT 14 to 49 ng/l (i.e., a group in which most patients would have had a negative cardiac troponin T with older assays); and Group 4, those wit...