Experiments indicate that depolymerization of microtubules generates sufficient force to produce the minus-end-directed transport of chromosomes during mitosis (Koshland et al., 1988). In vitro, analogous transport of kinesin-coated microspheres exhibits a paradoxical effect. Minus-end-directed transport of the microspheres driven by depolymerization is enhanced by the presence of ATP, which fuels the motor action of kinesin driving the microspheres in the opposite direction, toward the plus end of the microtubule. Here we present a mathematical model to explain this behavior. We postulate that a microsphere at the plus end of the microtubule facilitates depolymerization and hence enhances minus-end-directed transport. The force-velocity cu...
Single kinesin motor molecules were observed to buckle the microtubules along which they moved in a ...
Motor proteins, like kinesin, transport cargo within biological cells by transforming chemical energ...
In many intracellular processes, the length distribution of microtubules is controlled by depolymeri...
Experiments indicate that depolymerization of microtubules generates sufficient force to produce the...
AbstractIn this paper we present a model that simulates the role of microtubules in depolymerization...
More than 50 years ago, microtubule depolymerization was proposed as the force responsible for chrom...
AbstractThe assembly and disassembly dynamics of microtubules (MTs) is tightly controlled by MT-asso...
AbstractThe coupling between the depolymerization of microtubules (MTs) and the motion of the Dam1 r...
Length regulation of microtubules (MTs) is essential for many cellular processes. Molecular motors l...
AbstractProteins from the kinesin-8 family promote microtubule (MT) depolymerization, a process thou...
In many intracellular processes, the length distribution of microtubules is controlled by depolymeri...
The coupling between the depolymerization of microtubules (MTs) and the motion of the Dam1 ring comp...
Motor proteins that specifically interact with the ends of cytoskeletal filaments can induce filamen...
The coupling between the depolymerization of microtubules (MTs) and the motion of the Dam1 ring comp...
SummaryMotor proteins in the kinesin-8 family depolymerize microtubules in a length-dependent manner...
Single kinesin motor molecules were observed to buckle the microtubules along which they moved in a ...
Motor proteins, like kinesin, transport cargo within biological cells by transforming chemical energ...
In many intracellular processes, the length distribution of microtubules is controlled by depolymeri...
Experiments indicate that depolymerization of microtubules generates sufficient force to produce the...
AbstractIn this paper we present a model that simulates the role of microtubules in depolymerization...
More than 50 years ago, microtubule depolymerization was proposed as the force responsible for chrom...
AbstractThe assembly and disassembly dynamics of microtubules (MTs) is tightly controlled by MT-asso...
AbstractThe coupling between the depolymerization of microtubules (MTs) and the motion of the Dam1 r...
Length regulation of microtubules (MTs) is essential for many cellular processes. Molecular motors l...
AbstractProteins from the kinesin-8 family promote microtubule (MT) depolymerization, a process thou...
In many intracellular processes, the length distribution of microtubules is controlled by depolymeri...
The coupling between the depolymerization of microtubules (MTs) and the motion of the Dam1 ring comp...
Motor proteins that specifically interact with the ends of cytoskeletal filaments can induce filamen...
The coupling between the depolymerization of microtubules (MTs) and the motion of the Dam1 ring comp...
SummaryMotor proteins in the kinesin-8 family depolymerize microtubules in a length-dependent manner...
Single kinesin motor molecules were observed to buckle the microtubules along which they moved in a ...
Motor proteins, like kinesin, transport cargo within biological cells by transforming chemical energ...
In many intracellular processes, the length distribution of microtubules is controlled by depolymeri...