The effect of MinC on FtsZ polymerization is pH dependent and can be counteracted by ZapA
- Scheffers, Dirk-Jan
Publication date
July 2008
DOI Publisher
Federation of European Biochemical Societies. Published by Elsevier B.V. ISSN
0014-5793 Citation count (estimate)
42Abstract
AbstractThe min system prevents polar cell division in bacteria. Here, the biochemical characterization of the interaction of MinC and FtsZ from a Gram-positive bacterium, Bacillus subtilis, is reported. B. subtilis MinC inhibits FtsZ polymerization in a pH-dependent manner by preventing the formation of lateral associations between filaments. The inhibitory effect of MinC on FtsZ polymerization is counteracted by the presence of ZapA, a protein that promotes FtsZ filament bundling
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