In this issue of Cell, Lemoine et al. (2005) monitor chromosome instability in yeast cells with reduced levels of an essential replicative DNA polymerase. The authors identify a hotspot for chromosome aberrations reminiscent of fragile sites in human cells. This hotspot is composed of inverted Ty elements, which lead to a double-strand break under conditions of limited replication
Most cells of solid tumors have very high levels of genome instability of several different types, i...
The mechanism that replicates, maintains, and sometimes alters the DNA is most fundamental and impor...
To maintain genomic stability, reinitiation of eukaryotic DNA replication within a single cell cycle...
In this issue of Cell, Lemoine et al. (2005) monitor chromosome instability in yeast cells with redu...
SummaryIn the yeast Saccharomyces cerevisiae, reduced levels of the replicative α DNA polymerase res...
Chromosomal fragile sites are specific loci that exhibit instability visible as gaps and breaks on t...
Chromosomal fragile sites are specific loci that exhibit instability visible as gaps and breaks on t...
Chromosomal fragile sites are specific loci that exhibit instability visible as gaps and breaks on t...
Chromosomal fragile sites are specific loci that exhibit instability visible as gaps and breaks on t...
Chromosomal fragile sites are specific loci that exhibit instability visible as gaps and breaks on t...
One important source of genomic instability associated with tumor cells is DNA replication stress. I...
One important source of genomic instability associated with tumor cells is DNA replication stress. I...
DNA sequences capable of adopting non-canonical secondary structures have been associated with gross...
DNA sequences capable of adopting non-canonical secondary structures have been associated with gross...
SummaryGenomic rearrangements linked to aberrant recombination are associated with cancer and human ...
Most cells of solid tumors have very high levels of genome instability of several different types, i...
The mechanism that replicates, maintains, and sometimes alters the DNA is most fundamental and impor...
To maintain genomic stability, reinitiation of eukaryotic DNA replication within a single cell cycle...
In this issue of Cell, Lemoine et al. (2005) monitor chromosome instability in yeast cells with redu...
SummaryIn the yeast Saccharomyces cerevisiae, reduced levels of the replicative α DNA polymerase res...
Chromosomal fragile sites are specific loci that exhibit instability visible as gaps and breaks on t...
Chromosomal fragile sites are specific loci that exhibit instability visible as gaps and breaks on t...
Chromosomal fragile sites are specific loci that exhibit instability visible as gaps and breaks on t...
Chromosomal fragile sites are specific loci that exhibit instability visible as gaps and breaks on t...
Chromosomal fragile sites are specific loci that exhibit instability visible as gaps and breaks on t...
One important source of genomic instability associated with tumor cells is DNA replication stress. I...
One important source of genomic instability associated with tumor cells is DNA replication stress. I...
DNA sequences capable of adopting non-canonical secondary structures have been associated with gross...
DNA sequences capable of adopting non-canonical secondary structures have been associated with gross...
SummaryGenomic rearrangements linked to aberrant recombination are associated with cancer and human ...
Most cells of solid tumors have very high levels of genome instability of several different types, i...
The mechanism that replicates, maintains, and sometimes alters the DNA is most fundamental and impor...
To maintain genomic stability, reinitiation of eukaryotic DNA replication within a single cell cycle...
DOI
Add to ORKG