Introduction:Hereditary lung cancer syndromes are rare, and T790M germline mutations of the epidermal growth factor receptor (EGFR) gene predispose to the development of lung cancer. The goal of this study was to determine the clinical features and smoking status of lung cancer cases and unaffected family members with this germline mutation and to estimate its incidence and penetrance.Methods:We studied a family with germline T790M mutations over five generations (14 individuals) and combined our observations with data obtained from a literature search (15 individuals).Results:T790M germline mutations occurred in approximately 1% of non–small-cell lung cancer cases and in less than one in 7500 subjects without lung cancer. Both sporadic and...
IntroductionApproximately 50% of lung cancer patients with epidermal growth factor receptor (EGFR)-m...
Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants ...
BackgroundThe authors sought to define clinicopathologic features associated with mutations of the e...
Introduction:Hereditary lung cancer syndromes are rare, and T790M germline mutations of the epiderma...
IntroductionThe study of patients carrying germline endothelial growth factor receptor (EGFR) mutati...
Activating mutations in epidermal growth factor receptor (EGFR) are present in a subset of lung canc...
BackgroundEpidemiological surveys have suggested that lung cancer has inherited susceptibility and s...
BackgroundAccumulating evidence indicates inherited risk in the aetiology of lung cancer, although s...
Tyrosine kinase inhibitor (TKI) treatment directed against epidermal growth factor receptor (EGFR) h...
Five cases of non-small cell lung cancer, associated with germline transmission of epidermal growth ...
Objectives: Although the primary cause of lung cancer is smoking, a considerable proportion of all l...
Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants ...
Qiushi Wang,1 Jianghong Mou,1 Xin Yang,1 Yong He,2 Zengpeng Li,1 Qingya Luo,1 Yanqing Li,1 Li Lin,1 ...
Lung cancer is the deadliest cancer in the United States, killing roughly one of four cancer patient...
Somatic activating mutations in EGFR identify a subset of non-small cell lung cancer that respond to...
IntroductionApproximately 50% of lung cancer patients with epidermal growth factor receptor (EGFR)-m...
Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants ...
BackgroundThe authors sought to define clinicopathologic features associated with mutations of the e...
Introduction:Hereditary lung cancer syndromes are rare, and T790M germline mutations of the epiderma...
IntroductionThe study of patients carrying germline endothelial growth factor receptor (EGFR) mutati...
Activating mutations in epidermal growth factor receptor (EGFR) are present in a subset of lung canc...
BackgroundEpidemiological surveys have suggested that lung cancer has inherited susceptibility and s...
BackgroundAccumulating evidence indicates inherited risk in the aetiology of lung cancer, although s...
Tyrosine kinase inhibitor (TKI) treatment directed against epidermal growth factor receptor (EGFR) h...
Five cases of non-small cell lung cancer, associated with germline transmission of epidermal growth ...
Objectives: Although the primary cause of lung cancer is smoking, a considerable proportion of all l...
Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants ...
Qiushi Wang,1 Jianghong Mou,1 Xin Yang,1 Yong He,2 Zengpeng Li,1 Qingya Luo,1 Yanqing Li,1 Li Lin,1 ...
Lung cancer is the deadliest cancer in the United States, killing roughly one of four cancer patient...
Somatic activating mutations in EGFR identify a subset of non-small cell lung cancer that respond to...
IntroductionApproximately 50% of lung cancer patients with epidermal growth factor receptor (EGFR)-m...
Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants ...
BackgroundThe authors sought to define clinicopathologic features associated with mutations of the e...