Actinomycin D decreases protein kinase C content and induces neuritogenesis in neuroblastoma cells

AbstractWe have previously reported that inhibition of protein kinase C induces differentiation of neuroblastoma cells in culture. It is shown now that actinomycin D, a well known inhibitor of DNA synthesis, reduces selectively the content of protein kinase C and induces neuritogenesis in Neuro 2a cells in culture