New biomarkers and heart failure

Vondráková, Dagmar
Málek, Filip
Ošt׳ádal, Petr
Kru¨ger, Andreas
Neužil, Petr

Open PDF

Open link

Publication date

August 2013

DOI

10.1016/j.crvasa.2013.04.003

Publisher

The Czech Society of Cardiology. Published by Elsevier Sp. z o.o.

ISSN

0010-8650

Citation count (estimate)

Abstract

AbstractHeart failure is a major health problem with an increasing incidence and prevalence of the disease. The role of both established natriuretic peptides: B-type natriuretic peptide (BNP) and N-terminal prohormone pro-brain natriuretic peptide (NT-proBNP) in acute and chronic heart failure (HF) has been intensively studied. Its testing is routine in clinical practice for diagnosis and prognosis in HF. However, increased clarification and understanding of the interplay in the pathophysiology of HF revealed several new potential cardiac biomarkers. These novel biomarkers soluble ST2, galectin, copeptin and, mid-regional fragment of pro-adrenomedullin (MR-proADM) may aid in the diagnostic and prognostic evaluation of acute and chronic hear...