While the role of endogenous T cells in antitumor immunity is being debated, little is known about whether and how T cells promote tumorigenesis. In this issue of Cancer Cell, DeNardo and colleagues demonstrate that IL-4-producing T cells enhance metastasis by programming macrophages to produce factors that enhance tumor invasion
Metastasis â the spread of cancer from a primary to a distant secondary location â is implicated...
Immune cells actively influence, among other factors, each step of tumor development determining the...
The goal of this body of research was to elucidate the mechanism by which CD4+ T cells provide help ...
While the role of endogenous T cells in antitumor immunity is being debated, little is known about w...
SummaryDuring breast cancer development, increased presence of leukocytes in neoplastic stroma paral...
It is now widely accepted that T lymphocytes can participate in the elimination of tumor cells. T ce...
SummaryGene-targeted mice have recently revealed a role for lymphocytes and interferon-γ (IFNγ) in c...
Metastasis is an intricate process whereby tumor cells migrate from the primary tumor, survive in th...
Tumor antigen-specific CD4(+) T cells generally orchestrate and regulate immune cells to provide imm...
Although clinically apparent metastasis is associated with late stages of cancer development, micro-...
The exploitation of T cell-based immunotherapies and immune checkpoint blockade for cancer treatment...
Although the existence of an immune response against tumor cells is well documented, the fact that t...
The immune system interacts with developing cancer in ways that can protect the host against hyperpr...
Metastatic disease remains the primary cause of death for patients with breast cancer. The different...
Cancer immunoediting explains the dual role by which the immune system can both suppress and/or prom...
Metastasis â the spread of cancer from a primary to a distant secondary location â is implicated...
Immune cells actively influence, among other factors, each step of tumor development determining the...
The goal of this body of research was to elucidate the mechanism by which CD4+ T cells provide help ...
While the role of endogenous T cells in antitumor immunity is being debated, little is known about w...
SummaryDuring breast cancer development, increased presence of leukocytes in neoplastic stroma paral...
It is now widely accepted that T lymphocytes can participate in the elimination of tumor cells. T ce...
SummaryGene-targeted mice have recently revealed a role for lymphocytes and interferon-γ (IFNγ) in c...
Metastasis is an intricate process whereby tumor cells migrate from the primary tumor, survive in th...
Tumor antigen-specific CD4(+) T cells generally orchestrate and regulate immune cells to provide imm...
Although clinically apparent metastasis is associated with late stages of cancer development, micro-...
The exploitation of T cell-based immunotherapies and immune checkpoint blockade for cancer treatment...
Although the existence of an immune response against tumor cells is well documented, the fact that t...
The immune system interacts with developing cancer in ways that can protect the host against hyperpr...
Metastatic disease remains the primary cause of death for patients with breast cancer. The different...
Cancer immunoediting explains the dual role by which the immune system can both suppress and/or prom...
Metastasis â the spread of cancer from a primary to a distant secondary location â is implicated...
Immune cells actively influence, among other factors, each step of tumor development determining the...
The goal of this body of research was to elucidate the mechanism by which CD4+ T cells provide help ...
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