Simulation of Spontaneous Ca2+ Oscillations in Astrocytes Mediated by Voltage-Gated Calcium Channels

AbstractThe purpose of this computational study was to investigate the possible role of voltage-gated Ca2+ channels in spontaneous Ca2+ oscillations of astrocytes. By incorporating different types of voltage-gated Ca2+ channels and a previous model, this study reproduced typical Ca2+ oscillations in silico. Our model could mimic the oscillatory phenomenon under a wide range of experimental conditions, including resting membrane potential (−75 to −60 mV), extracellular Ca2+ concentration (0.1 to 1500 μM), temperature (20 to 37°C), and blocking specific Ca2+ channels. By varying the experimental conditions, the amplitude and duration of Ca2+ oscillations changed slightly (both