Antigen presentation by dendritic cells in renal lymph nodes is linked to systemic and local injury to the kidney.BackgroundDendritic cells (DCs) uniquely serve as conduits between innate and cognate arms of the immune system. The normal kidney contains an extensive population of interstitial DCs but their role in the pathogenesis of acute renal injury is not known.MethodsRenal DCs were studied by flow cytometric analysis of collagenase-digested mouse kidneys, by immunohistochemistry, and by immunofluorescence microscopy. In vivo ingestion by DCs of intravenously administered fluorescein isothiocyanate (FITC)-dextran particles was examined. A model antigen system (presentation of ovalbumin-derived peptide to TCR transgenic CD4+ T-cells) was...
Acute urinary obstruction causes interstitial inflammation with leukocyte accumulation and the secre...
Renal ischemia–reperfusion injury is a major cause of acute renal failure and kidney allograft dysfu...
Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as mast...
Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as mast...
Dendritic cells (DCs) are potent antigen presenting cells making them critical mediators of the adap...
Renal ischemia–reperfusion injury (IRI) rapidly induces production of inflammatory mediators includi...
Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as mast...
Dendritic cells (DCs) are crucial for inducing and regulating adaptive immunity. These cells also ex...
The progression of kidney disease to renal failure correlates with infiltration of mononuclear immun...
Dendritic cells (DCs) play critical roles in immune responses and can be distinguished in two major ...
Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as mast...
Dendritic cells (DCs) form a bridge between the innate and adaptive immune systems and fundamentally...
Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as mast...
Dendritic cells (DCs) interface innate and adaptive immunity in nonlymphoid organs; however, the exa...
Dendritic cells (DCs) are a family of antigen presenting cells that play a paramount role in bridgin...
Acute urinary obstruction causes interstitial inflammation with leukocyte accumulation and the secre...
Renal ischemia–reperfusion injury is a major cause of acute renal failure and kidney allograft dysfu...
Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as mast...
Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as mast...
Dendritic cells (DCs) are potent antigen presenting cells making them critical mediators of the adap...
Renal ischemia–reperfusion injury (IRI) rapidly induces production of inflammatory mediators includi...
Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as mast...
Dendritic cells (DCs) are crucial for inducing and regulating adaptive immunity. These cells also ex...
The progression of kidney disease to renal failure correlates with infiltration of mononuclear immun...
Dendritic cells (DCs) play critical roles in immune responses and can be distinguished in two major ...
Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as mast...
Dendritic cells (DCs) form a bridge between the innate and adaptive immune systems and fundamentally...
Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as mast...
Dendritic cells (DCs) interface innate and adaptive immunity in nonlymphoid organs; however, the exa...
Dendritic cells (DCs) are a family of antigen presenting cells that play a paramount role in bridgin...
Acute urinary obstruction causes interstitial inflammation with leukocyte accumulation and the secre...
Renal ischemia–reperfusion injury is a major cause of acute renal failure and kidney allograft dysfu...
Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as mast...