The PML protein induces senescence, and, upon oncogenic stress, its absence promotes cellular transformation. In this issue of Cell, Scaglioni et al. (2006) show that phosphorylation of PML by CK2, a kinase frequently activated in human cancers, promotes PML degradation. Therefore, pharmacological inhibition of CK2-induced PML loss could be used to offset tumor establishment
EGFR kinase inhibitors constitute an important class of lung cancer treatments. While they produce d...
In a recent paper in PNAS, Rigoutsos et al. (2006) describe a nonrandom pattern of repeated elements...
In this issue of Cell, Midorikawa et al. (2006) demonstrate that the kinesin superfamily member KIF4...
In this issue of Cell, Axel and colleagues (Lomvardas et al., 2006) report that a single enhancer of...
The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints ...
Destruction of intact cellular proteins is largely orchestrated by ATP-dependent ubiquitination and ...
The protein tyrosine phosphatase PTP1B, previously recognized for its role in downregulating insulin...
In this issue of Cell, Guenther et al. (2007) analyze the presence of chromatin marks and RNA polyme...
The pattern of histone modifications, called the histone code, influences transitions between chroma...
Limitations on a differentiated cell's pluripotency can be erased by nuclear transfer or by fusion w...
Fish and amphibian hearts are known to regenerate after partial resection, but the molecular mechani...
Caspase-1 promotes both the maturation of proinflammatory cytokines and apoptosis in cells infected ...
Skin, the largest organ of our body, is often plagued by cancer because of exposure to ultraviolet r...
In this issue of Cell, Feng et al. (2006) report a worm model of nicotine dependence that shows beha...
In this issue of Cell, Grosschedl and colleagues (Dobreva et al., 2006) report that the nuclear matr...
EGFR kinase inhibitors constitute an important class of lung cancer treatments. While they produce d...
In a recent paper in PNAS, Rigoutsos et al. (2006) describe a nonrandom pattern of repeated elements...
In this issue of Cell, Midorikawa et al. (2006) demonstrate that the kinesin superfamily member KIF4...
In this issue of Cell, Axel and colleagues (Lomvardas et al., 2006) report that a single enhancer of...
The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints ...
Destruction of intact cellular proteins is largely orchestrated by ATP-dependent ubiquitination and ...
The protein tyrosine phosphatase PTP1B, previously recognized for its role in downregulating insulin...
In this issue of Cell, Guenther et al. (2007) analyze the presence of chromatin marks and RNA polyme...
The pattern of histone modifications, called the histone code, influences transitions between chroma...
Limitations on a differentiated cell's pluripotency can be erased by nuclear transfer or by fusion w...
Fish and amphibian hearts are known to regenerate after partial resection, but the molecular mechani...
Caspase-1 promotes both the maturation of proinflammatory cytokines and apoptosis in cells infected ...
Skin, the largest organ of our body, is often plagued by cancer because of exposure to ultraviolet r...
In this issue of Cell, Feng et al. (2006) report a worm model of nicotine dependence that shows beha...
In this issue of Cell, Grosschedl and colleagues (Dobreva et al., 2006) report that the nuclear matr...
EGFR kinase inhibitors constitute an important class of lung cancer treatments. While they produce d...
In a recent paper in PNAS, Rigoutsos et al. (2006) describe a nonrandom pattern of repeated elements...
In this issue of Cell, Midorikawa et al. (2006) demonstrate that the kinesin superfamily member KIF4...
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